ENSMUSG00000041578


Mus musculus

Features
Gene ID: ENSMUSG00000041578
  
Biological name :Crx
  
Synonyms : Cone-rod homeobox protein / Crx / O54751
  
Possible biological names infered from orthology : cone-rod homeobox / O43186
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 15865947
Gene end: 15879968
  
Corresponding Affymetrix probe sets: 10560168 (MoGene1.0st)   1418705_at (Mouse Genome 430 2.0 Array)   1449185_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043436
Ensembl peptide - ENSMUSP00000133833
Ensembl peptide - ENSMUSP00000134400
Ensembl peptide - ENSMUSP00000134463
NCBI entrez gene - 12951     See in Manteia.
MGI - MGI:1194883
RefSeq - NM_001113330
RefSeq - NM_007770
RefSeq Peptide - NP_001106801
RefSeq Peptide - NP_031796
swissprot - Q543C9
swissprot - A0A0A0MQN6
swissprot - G3UXU9
swissprot - G3UZE2
swissprot - O54751
Ensembl - ENSMUSG00000041578
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CRXENSG00000105392Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otx2 / orthodenticle homeobox 2 / P32243*ENSMUSG0000002184848
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*ENSMUSG0000000591743
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSMUSG0000002870724
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*ENSMUSG0000002802321
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*ENSMUSG0000002150621
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*ENSMUSG0000002522920
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*ENSMUSG0000004454217
Prrx2 / paired related homeobox 2 / Q99811*ENSMUSG0000003947615
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*ENSMUSG0000002658615
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*ENSMUSG0000002649715
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*ENSMUSG0000002109514
Gsc2 / goosecoid homeobox 2 / O15499*ENSMUSG0000002273813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR013851  Transcription factor Otx, C-terminal
 IPR017970  Homeobox, conserved site
 IPR032966  Cone-rod homeobox protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046534 positive regulation of photoreceptor cell differentiation IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IPI
 molecular_functionGO:0043522 leucine zipper domain binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

Allelic Composition: CrxRip/CrxRip
Genetic Background: C57BL/6J-CrxRip

Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crxtm1.1Smgc/Crxtm1.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm1Smgc/Crx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Crxtm2.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm2.1Smgc

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Usp7tm2Wgu/Usp7tm2Wgu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1.1Smgc/Crxtm1.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm2.1Smgc/Crxtm2.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm2.1Smgc

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: CrxRip/CrxRip
Genetic Background: C57BL/6J-CrxRip

Allelic Composition: Crxtm1Clc/Crxtm1Clc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

 MP:0006075 abnormal retinal cone bipolar cell morphology "anomalous structure of the retinal bipolar cells that connect to both ganglion and amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm1Smgc/Crx+
Genetic Background: involves: 129X1/SvJ

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtvrm65/Crxtvrm65
Genetic Background: C57BL/6J-Crxtvrm65/J

Allelic Composition: Crxtm1.1Smgc/Crxtm1.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm2.1Smgc/Crxtm2.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm2.1Smgc

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crxtvrm65/Crxtvrm65
Genetic Background: C57BL/6J-Crxtvrm65/J

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

 MP:0008583 absent photoreceptor inner segment "absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crxtvrm65/Crxtvrm65
Genetic Background: C57BL/6J-Crxtvrm65/J

Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtvrm65/Crxtvrm65
Genetic Background: C57BL/6J-Crxtvrm65/J

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

Allelic Composition: Crxtm1.1Smgc/Crxtm1.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm2.1Smgc/Crxtm2.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm2.1Smgc

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

 MP:0011997 abnormal retinal outer nuclear layer thickness "anomaly in the thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:csmith]
Show

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

Allelic Composition: Crxtm1.1Smgc/Crxtm1.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm1Smgc/Crx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Crxtm2.1Smgc/Crxtm2.1Smgc
Genetic Background: B6.129X1(CBA)-Crxtm2.1Smgc

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Crxtm1.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm1.1Smgc

Allelic Composition: Crxtm2.1Smgc/Crx+
Genetic Background: B6.129X1(CBA)-Crxtm2.1Smgc

 MP:0012671 retinal spots "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [MGI:csmith]
Show

Allelic Composition: CrxRip/Crx+
Genetic Background: C57BL/6J-CrxRip

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

 MP:0020475 delayed circadian behavior phase "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Oca2p-bs/Oca2p-bs
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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