ENSMUSG00000044542


Mus musculus

Features
Gene ID: ENSMUSG00000044542
  
Biological name :Prop1
  
Synonyms : Homeobox protein prophet of Pit-1 / P97458 / Prop1
  
Possible biological names infered from orthology : O75360 / PROP paired-like homeobox 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 50950806
Gene end: 50953765
  
Corresponding Affymetrix probe sets: 10385677 (MoGene1.0st)   1450361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125413
Ensembl peptide - ENSMUSP00000057231
NCBI entrez gene - 19127     See in Manteia.
MGI - MGI:109330
RefSeq - NM_008936
RefSeq Peptide - NP_032962
swissprot - E0CZF7
swissprot - P97458
Ensembl - ENSMUSG00000044542
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PROP1ENSG00000175325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otx2 / orthodenticle homeobox 2 / P32243*ENSMUSG0000002184828
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*ENSMUSG0000000591726
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSMUSG0000002870725
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*ENSMUSG0000004157824
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*ENSMUSG0000002150623
Prrx2 / paired related homeobox 2 / Q99811*ENSMUSG0000003947623
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*ENSMUSG0000002649723
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*ENSMUSG0000002522922
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*ENSMUSG0000002658622
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*ENSMUSG0000002802322
Gsc2 / goosecoid homeobox 2 / O15499*ENSMUSG0000002273822
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*ENSMUSG0000002109519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0021979 hypothalamus cell differentiation IMP
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048732 gland development IMP
 biological_processGO:0048850 hypophysis morphogenesis IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IGI
 biological_processGO:0060126 somatotropin secreting cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Prop1df/Prop1df
Genetic Background: DF

 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Prop1df/Prop1df
Genetic Background: involves: C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002659 pituitary gland hypoplasia "decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Prop1df/Prop1df
Genetic Background: DF

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0003348 hypopituitarism "reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
Show

Allelic Composition: Prop1df/Prop1df
Genetic Background: DF

 MP:0003972 decreased pituitary hormone level "less than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0005119 decreased circulating thyroid-stimulating hormone level "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008320 absent adenohypophysis "absence of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008330 absent somatotrophs "absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008336 absent gonadotrophs "absence of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0008338 decreased thyrotroph cell number "reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008365 adenohypophysis hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm1Kel/Igf2+,Phlda2tm2Bty/Phlda2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prop1tm1Sac/Prop1tm1Sac
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0013337 abnormal adenohypophysis development "aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke s) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia" [MGI:Anna]
Show

Allelic Composition: Ss18tm1Adg/Ss18tm1Adg
Genetic Background: B6.Cg-Ss18tm1Adg

 MP:0013349 small Rathke s pouch "reduced size of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0013351 abnormal Rathke s pouch development "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0013352 abnormal Rathke s pouch apoptosis "any change in the timing or number of Rathke s pouch cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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