ENSMUSG00000021848


Mus musculus

Features
Gene ID: ENSMUSG00000021848
  
Biological name :Otx2
  
Synonyms : orthodenticle homeobox 2 / Otx2
  
Possible biological names infered from orthology : P32243
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 48657677
Gene end: 48673819
  
Corresponding Affymetrix probe sets: 10419356 (MoGene1.0st)   1425926_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122200
Ensembl peptide - ENSMUSP00000116630
Ensembl peptide - ENSMUSP00000123454
Ensembl peptide - ENSMUSP00000154264
Ensembl peptide - ENSMUSP00000154066
Ensembl peptide - ENSMUSP00000112532
Ensembl peptide - ENSMUSP00000113586
Ensembl peptide - ENSMUSP00000113690
Ensembl peptide - ENSMUSP00000113930
NCBI entrez gene - 18424     See in Manteia.
MGI - MGI:97451
RefSeq - XM_017315917
RefSeq - NM_001286481
RefSeq - NM_001286482
RefSeq - NM_001286483
RefSeq - NM_144841
RefSeq - XM_011244988
RefSeq - XM_011244989
RefSeq - XM_017315913
RefSeq - XM_017315914
RefSeq - XM_017315915
RefSeq - XM_017315916
RefSeq Peptide - NP_659090
RefSeq Peptide - NP_001273410
RefSeq Peptide - NP_001273411
RefSeq Peptide - NP_001273412
swissprot - D3Z7L5
swissprot - D3YZ94
swissprot - Q8VD35
swissprot - D3Z581
swissprot - D3Z4G2
swissprot - Q8R0B5
Ensembl - ENSMUSG00000021848
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otx2bENSDARG00000011235Danio rerio
 OTX2ENSGALG00000034889Gallus gallus
 OTX2ENSG00000165588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*ENSMUSG0000000591768
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*ENSMUSG0000004157852
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSMUSG0000002870729
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*ENSMUSG0000002150625
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*ENSMUSG0000002802324
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*ENSMUSG0000002522922
Prrx2 / paired related homeobox 2 / Q99811*ENSMUSG0000003947621
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*ENSMUSG0000004454221
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*ENSMUSG0000002658620
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*ENSMUSG0000002649716
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*ENSMUSG0000002109515
Gsc2 / goosecoid homeobox 2 / O15499*ENSMUSG0000002273814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003022  Transcription factor Otx2
 IPR003025  Transcription factor Otx
 IPR009057  Homeobox-like domain superfamily
 IPR013851  Transcription factor Otx, C-terminal
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000104 abnormal sphenoid bone morphology "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm9Asim/Otx2tm9Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: TSJ/Le

Allelic Composition: Otx2tm5(OTX2)Asim/Otx2tm5(OTX2)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm10Asim/Otx2tm10Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm10Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm12.1Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

 MP:0000776 abnormal inferior colliculus "dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx2tm1Sia/Emx2+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm10Asim/Otx2tm10Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm9Sia/Otx2tm9Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx2tm1Sia/Otx2tm9Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx2tm1Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000809 absent hippocampus "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Rxfp2tm1Aia/Rxfp2tm1c(EUCOMM)Wtsi,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL

Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000847 abnormal metencephalon morphology "any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Otx1tm1Asim/Otx1tm2(otd)Asim,Otx2tm1Pas/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

Allelic Composition: Otx1tm1Asim/Otx1tm2(otd)Asim,Otx2tm1Pas/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx1tm2(otd)Asim/Otx1tm2(otd)Asim,Otx2tm1Pas/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000906 abnormal mesencephalic trigeminal nucleus "malformation or disorganization of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sia/Otx2tm6Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm3(otd)Asim/Otx2tm3(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Otx2tm9Asim/Otx2tm9Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sla/Otx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001061 abnormal oculomotor nerve morphology "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001063 abnormal trochlear nerve morphology "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Otx2tm1.2Tlam/Otx2tm1.2Tlam
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Otx2tm4(otd)Asim/Otx2tm4(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001329 retina hyperplasia "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm9Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm10Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001684 abnormal axial mesoderm "malformed middle primary germ layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:51834]
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 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1.2Tlam/Otx2tm1.2Tlam
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Otx1tm2(otd)Asim/Otx1tm2(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Otx2tm4.1Sia/Otx2tm4.1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm4.2Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA * FVB/N

Allelic Composition: Otx2tm1Sia/Otx2tm4.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

Allelic Composition: Otx2tm8Asim/Otx2tm8Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002237 abnormal nasal cavity morphology "any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002243 abnormal vomeronasal organ morphology "any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002251 abnormal nasopharynx morphology "structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002698 abnormal sclera morphology "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003006 abnormal hippocampal fornix "malformations in the compact, white, heavily myelinated fiber bundle arising from the Ammon horn of the hippocampus in each cerebral hemisphere and projecting to the hypothalamus and the mammillary body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

Allelic Composition: Otx2tm2Imat/Otx2tm7Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm3(otd)Asim/Otx2tm3(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm5(OTX2)Asim/Otx2tm5(OTX2)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm9Asim/Otx2tm9Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm9Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm5(OTX2)Asim/Otx2tm5(OTX2)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm9Asim/Otx2tm9Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm9Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0003874 absent branchial arches "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003877 abnormal serotonergic neuron morphology "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm12.1Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004096 abnormal midbrain-hindbrain boundary development "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm3(otd)Asim/Otx2tm3(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004162 abnormal mammilary body morphology "any malformation or absence of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Otx2tm9Sia/Otx2tm9Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx2tm1Sia/Otx2tm9Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx2tm1Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004280 abnormal oculomotor nucleus morphology "any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004448 abnormal presphenoid bone morphology "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004450 presphenoid bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004457 abnormal orbitosphenoid bone morphology "any structural anomaly of the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004463 basisphenoid bone foramen "the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004539 absent maxilla "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0004872 absent nasal septum "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004912 absent mandibular coronoid process "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004990 abnormal ciliary ganglion morphology "any anomaly of the parasympathetic ganglia in the orbit behind the eye that receives preganglionic innervation through the oculomotor nerve" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005247 abnormal extraocular muscle morphology "structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferrior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005261 aniridia "abnormality in which there is only a rudimentary iris, due to the failure of optic cup growth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005315 absent pituitary gland "missing gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
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Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005549 retinal pigment epithelium hyperplasia "increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006100 abnormal tegmentum morphology "any structural alterations or malfunction of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0006101 absent tegmentum "absence or loss of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0006105 reduced tectum size "reduced size of the rostral part of the midbrain roof" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006106 absent tectum "absence or loss of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Sla/Otx2tm2Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006293 absent olfactory placodes "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0006294 absent optic vesicle "absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm12.1Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm4(otd)Asim/Otx2tm4(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008262 abnormal hippocampus region morphology "any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008325 abnormal gonadotroph morphology "any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Bcl11btm2Jpk/Bcl11b+,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: C57BL/6

 MP:0008384 absent nasal capsule "absence of the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm12.1Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm12.1Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm12.1Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm12.1Asim/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008914 enlarged cerebellum "increased size of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1.1(cre/ERT2)Mgoe/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam
Genetic Background: Not Specified

 MP:0009048 enlarged tectum "increased size of the rostral part of the midbrain roof" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0009324 absent hippocampal fimbria "absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.464.265, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009578 otocephaly "a structural anomaly of the head consisting of absence or malformation of the lower jaw and the ears united or closely approaching below the face" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0009579 acephaly "congenital absence of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm2Imat/Otx2tm2Imat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm3(otd)Asim/Otx2tm3(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm4(otd)Asim/Otx2tm4(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm5(OTX2)Asim/Otx2tm5(OTX2)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm9Asim/Otx2tm9Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Otx2tm9Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0009637 abnormal pretectal region morphology "any structural anomaly of a narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light reflex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm3(Emx2)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010893 abnormal posterior commissure morphology "any structural anomaly of the band of nerve fiber tracts that span the longitudinal fissure beneath the habenula of the pineal body and over the cerebral aqueduct, interconnecting the left and right pretectal regions and some midbrain nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010940 abnormal maxillary prominence morphology 
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Allelic Composition: Otx2tm4(otd)Asim/Otx2tm4(otd)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Otx2tm2(Otx1)Sia/Otx2tm2(Otx1)Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm12.1Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Otx1tm1Asim/Otx1tm2(otd)Asim,Otx2tm1Pas/Otx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Otx2tm11Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sla/Otx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Otx2tm1Pas/Otx2+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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 MP:0012083 absent foregut "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm2Imat/Otx2tm7Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sla/Otx2tm2Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0012090 midbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Otx2tm12.1Asim/Otx2tm11Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0012132 abnormal midbrain-hindbrain boundary morphology "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm4(cre)Asim/Otx1+,Otx2tm6Asim/Otx2tm6.1Asim
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0012133 absent midbrain-hindbrain boundary "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Otx2tm1.2Tlam/Otx2tm1.2Tlam
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm2Imat/Otx2tm7Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sla/Otx2tm2Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Otx2tm2Asim/Otx2tm2Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Pas/Otx2tm1Pas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0012170 absent optic placodes "absence of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [MGI:anna]
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Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1Pas/Otx2tm2Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0012247 absent cornea "absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012267 abnormal red nucleus morphology "any anomaly of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination" [MGI:anna]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012276 absent prechordal mesoderm "absence of or failure to form the area of axial mesoderm that develops into the prechordal plate" [MGI:anna]
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 MP:0012516 absent metencephalon "absence of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain normally composed of the cerebellum and the pons Varolii" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012517 absent diencephalon "absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx2tm1Sia/Emx2tm1Sia,Otx2tm7Sia/Otx2tm7Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx2tm3Sia/Emx2tm3Sia,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Emx2tm3.1Sia/Emx2tm3.1Sia,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0012525 abnormal rhombic lip morphology "any structural anomaly of the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system" [MGI:anna]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012786 increased rhombomere 1 size "increased size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0013595 absent vomeronasal organ "lacking the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0013906 absent embryonic telencephalon "absence of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [MGI:Anna]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt,Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
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 MP:0020516 abnormal visceral yolk sac mesenchyme morphology "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
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 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0020534 increased pons size "increased size of or number of the nerve fibers in the pons" [MGI:smb]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0020543 decreased substantia nigra size "decreased size of the substantia nigra" [MGI:smb]
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Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0030102 absent orbitosphenoid bone "missing the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young" [MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0030320 abnormal temporal bone tympanic part morphology "any structural anomaly of the curved plate of bone that is situated inferiorly to the squamous part and anteriorly to the mastoid part of the temporal bone; it surrounds the external auditory meatus, forming the anterior wall, floor and some of the posterior wall of the bony external acoustic meatus; its lateral border gives the attachment to the cartilaginous part of the external acoustic meatus; its anteroinferior surface forms the posterior boundary of the mandibular fossa" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone, https://radiopaedia.org/articles/tympanic-part-of-temporal-bone]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0030324 abnormal anterior head development "any anomaly in the process in which the anatomical structures of the anterior part of the head are generated and organized" [GO:0097065, MGI:anna]
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Allelic Composition: Otx2tm1Sia/Otx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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