ENSMUSG00000026497


Mus musculus

Features
Gene ID: ENSMUSG00000026497
  
Biological name :Mixl1
  
Synonyms : Homeobox protein MIXL1 / Mixl1 / Q9WUI0
  
Possible biological names infered from orthology : Mix paired-like homeobox / Q9H2W2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H4
Gene start: 180693043
Gene end: 180697034
  
Corresponding Affymetrix probe sets: 10360674 (MoGene1.0st)   1421505_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027778
NCBI entrez gene - 27217     See in Manteia.
MGI - MGI:1351322
RefSeq - NM_013729
RefSeq - XM_006496871
RefSeq Peptide - NP_038757
swissprot - Q9WUI0
Ensembl - ENSMUSG00000026497
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mixl1ENSDARG00000069252Danio rerio
 MIXL1ENSG00000185155Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsc2 / goosecoid homeobox 2 / O15499*ENSMUSG0000002273823
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSMUSG0000002870723
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*ENSMUSG0000004454222
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*ENSMUSG0000000591722
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*ENSMUSG0000002150621
Otx2 / orthodenticle homeobox 2 / P32243*ENSMUSG0000002184821
Prrx2 / paired related homeobox 2 / Q99811*ENSMUSG0000003947621
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*ENSMUSG0000004157821
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*ENSMUSG0000002658620
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*ENSMUSG0000002109519
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*ENSMUSG0000002802319
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*ENSMUSG0000002522918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035987 endodermal cell differentiation IDA
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:1901533 negative regulation of hematopoietic progenitor cell differentiation IDA
 biological_processGO:2000382 positive regulation of mesoderm development IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0011256 abnormal neural fold morphology "any structural anomaly of the elevated margins of the neural groove" [ISBN:0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0012086 absent hindgut "absence of the caudal portion of the primitive digestive tube of the embryo" [MGI:anna]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

 MP:0012739 abnormal anterior primitive streak morphology "any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [MGI:anna]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mixl1tm1.1Robb/Mixl1tm1.1Robb
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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