ENSG00000185155


Homo sapiens

Features
Gene ID: ENSG00000185155
  
Biological name :MIXL1
  
Synonyms : MIXL1 / Mix paired-like homeobox / Q9H2W2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.12
Gene start: 226223618
Gene end: 226227054
  
Corresponding Affymetrix probe sets: 231746_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442439
Ensembl peptide - ENSP00000355775
NCBI entrez gene - 83881     See in Manteia.
OMIM - 609852
RefSeq - NM_001282402
RefSeq - NM_031944
RefSeq Peptide - NP_001269331
RefSeq Peptide - NP_114150
swissprot - Q9H2W2
swissprot - A0A024R3T7
Ensembl - ENSG00000185155
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mixl1ENSDARG00000069252Danio rerio
 Mixl1ENSMUSG00000026497Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PROP1 / O75360 / PROP paired-like homeobox 1ENSG0000017532528
GSC2 / O15499 / goosecoid homeobox 2ENSG0000006351524
OTX2 / P32243 / orthodenticle homeobox 2ENSG0000016558823
DMBX1 / Q8NFW5 / diencephalon/mesencephalon homeobox 1ENSG0000019758723
PITX1 / P78337 / paired like homeodomain 1ENSG0000006901122
OTX1 / P32242 / orthodenticle homeobox 1ENSG0000011550722
CRX / O43186 / cone-rod homeoboxENSG0000010539222
PRRX2 / Q99811 / paired related homeobox 2ENSG0000016715721
GSC / P56915 / goosecoid homeoboxENSG0000013393720
PITX2 / Q99697 / paired like homeodomain 2ENSG0000016409320
PRRX1 / P54821 / paired related homeobox 1ENSG0000011613220
PITX3 / O75364 / paired like homeodomain 3ENSG0000010785917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation ISS
 biological_processGO:0007492 endoderm development ISS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035987 endodermal cell differentiation ISS
 biological_processGO:0042074 cell migration involved in gastrulation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048565 digestive tract development ISS
 biological_processGO:1901533 negative regulation of hematopoietic progenitor cell differentiation ISS
 biological_processGO:2000382 positive regulation of mesoderm development ISS
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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