ENSG00000197587


Homo sapiens

Features
Gene ID: ENSG00000197587
  
Biological name :DMBX1
  
Synonyms : diencephalon/mesencephalon homeobox 1 / DMBX1 / Q8NFW5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p33
Gene start: 46506996
Gene end: 46514226
  
Corresponding Affymetrix probe sets: 234776_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353132
Ensembl peptide - ENSP00000361024
NCBI entrez gene - 127343     See in Manteia.
OMIM - 607410
RefSeq - XM_017000289
RefSeq - NM_147192
RefSeq - NM_172225
RefSeq - XM_011540668
RefSeq Peptide - NP_671725
RefSeq Peptide - NP_757379
swissprot - Q8NFW5
Ensembl - ENSG00000197587
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmbx1aENSDARG00000009922Danio rerio
 dmbx1bENSDARG00000002510Danio rerio
 DMBX1ENSGALG00000010436Gallus gallus
 Dmbx1ENSMUSG00000028707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTX2 / P32243 / orthodenticle homeobox 2ENSG0000016558823
PITX1 / P78337 / paired like homeodomain 1ENSG0000006901121
PITX2 / Q99697 / paired like homeodomain 2ENSG0000016409321
CRX / O43186 / cone-rod homeoboxENSG0000010539221
PITX3 / O75364 / paired like homeodomain 3ENSG0000010785920
OTX1 / P32242 / orthodenticle homeobox 1ENSG0000011550720
PRRX1 / P54821 / paired related homeobox 1ENSG0000011613218
PRRX2 / Q99811 / paired related homeobox 2ENSG0000016715717
PROP1 / O75360 / PROP paired-like homeobox 1ENSG0000017532516
GSC2 / O15499 / goosecoid homeobox 2ENSG0000006351514
MIXL1 / Q9H2W2 / Mix paired-like homeoboxENSG0000018515514
GSC / P56915 / goosecoid homeoboxENSG0000013393713


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development ISS
 biological_processGO:0007420 brain development ISS
 biological_processGO:0008343 adult feeding behavior IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048589 developmental growth ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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