ENSG00000115507


Homo sapiens

Features
Gene ID: ENSG00000115507
  
Biological name :OTX1
  
Synonyms : orthodenticle homeobox 1 / OTX1 / P32242
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p15
Gene start: 63050057
Gene end: 63057836
  
Corresponding Affymetrix probe sets: 238839_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282549
Ensembl peptide - ENSP00000385782
Ensembl peptide - ENSP00000355631
NCBI entrez gene - 5013     See in Manteia.
OMIM - 600036
RefSeq - NM_001199770
RefSeq - NM_014562
RefSeq Peptide - NP_001186699
RefSeq Peptide - NP_055377
swissprot - B5MC54
swissprot - P32242
Ensembl - ENSG00000115507
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otx1ENSDARG00000094992Danio rerio
 OTX1ENSGALG00000028817Gallus gallus
 Otx1ENSMUSG00000005917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTX2 / P32243 / orthodenticle homeobox 2ENSG0000016558857
CRX / O43186 / cone-rod homeoboxENSG0000010539240
DMBX1 / Q8NFW5 / diencephalon/mesencephalon homeobox 1ENSG0000019758722
PITX1 / P78337 / paired like homeodomain 1ENSG0000006901120
PROP1 / O75360 / PROP paired-like homeobox 1ENSG0000017532518
PRRX2 / Q99811 / paired related homeobox 2ENSG0000016715718
PITX3 / O75364 / paired like homeodomain 3ENSG0000010785918
PITX2 / Q99697 / paired like homeodomain 2ENSG0000016409318
PRRX1 / P54821 / paired related homeobox 1ENSG0000011613217
MIXL1 / Q9H2W2 / Mix paired-like homeoboxENSG0000018515515
GSC / P56915 / goosecoid homeoboxENSG0000013393714
GSC2 / O15499 / goosecoid homeobox 2ENSG0000006351511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003025  Transcription factor Otx
 IPR003026  Transcription factor Otx1
 IPR009057  Homeobox-like domain superfamily
 IPR013851  Transcription factor Otx, C-terminal
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0022037 metencephalon development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048852 diencephalon morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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