ENSMUSG00000028707


Mus musculus

Features
Gene ID: ENSMUSG00000028707
  
Biological name :Dmbx1
  
Synonyms : Diencephalon/mesencephalon homeobox protein 1 / Dmbx1 / Q91ZK4
  
Possible biological names infered from orthology : diencephalon/mesencephalon homeobox 1 / Q8NFW5
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 115915119
Gene end: 115939926
  
Corresponding Affymetrix probe sets: 10515213 (MoGene1.0st)   1460277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081366
Ensembl peptide - ENSMUSP00000120320
Ensembl peptide - ENSMUSP00000134457
NCBI entrez gene - 140477     See in Manteia.
MGI - MGI:2153518
RefSeq - XM_017319959
RefSeq - NM_001025567
RefSeq - NM_130865
RefSeq - XM_011240436
RefSeq - XM_017319957
RefSeq - XM_017319958
RefSeq Peptide - NP_570935
RefSeq Peptide - NP_001020738
swissprot - Q91ZK4
Ensembl - ENSMUSG00000028707
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmbx1aENSDARG00000009922Danio rerio
 dmbx1bENSDARG00000002510Danio rerio
 DMBX1ENSGALG00000010436Gallus gallus
 DMBX1ENSG00000197587Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otx2 / orthodenticle homeobox 2 / P32243*ENSMUSG0000002184823
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*ENSMUSG0000002150622
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*ENSMUSG0000002522921
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*ENSMUSG0000004157821
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*ENSMUSG0000002802320
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*ENSMUSG0000000591720
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*ENSMUSG0000002658618
Prrx2 / paired related homeobox 2 / Q99811*ENSMUSG0000003947617
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*ENSMUSG0000004454215
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*ENSMUSG0000002649714
Gsc2 / goosecoid homeobox 2 / O15499*ENSMUSG0000002273813
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*ENSMUSG0000002109513


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IEP
 biological_processGO:0007420 brain development IEP
 biological_processGO:0008343 adult feeding behavior IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048589 developmental growth IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmbx1tm1Sse/Dmbx1tm1Sse,Lepob/Lepob
Genetic Background: involves: ICR

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ay/a,Dmbx1tm1Sse/Dmbx1tm1Sse
Genetic Background: involves: ICR

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Dmbx1tm2Bhr/Dmbx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Dmbx1tm2Bhr/Dmbx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmbx1tm1Aoh/Dmbx1tm1Aoh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dmbx1tm2Aoh/Dmbx1tm2Aoh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr