ENSMUSG00000021506


Mus musculus

Features
Gene ID: ENSMUSG00000021506
  
Biological name :Pitx1
  
Synonyms : P70314 / paired-like homeodomain transcription factor 1 / Pitx1
  
Possible biological names infered from orthology : P78337 / paired like homeodomain 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55825051
Gene end: 55836192
  
Corresponding Affymetrix probe sets: 10409551 (MoGene1.0st)   1419514_at (Mouse Genome 430 2.0 Array)   1449488_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021968
Ensembl peptide - ENSMUSP00000134609
NCBI entrez gene - 18740     See in Manteia.
MGI - MGI:107374
RefSeq - XM_006517158
RefSeq - NM_011097
RefSeq - XM_006517157
RefSeq Peptide - NP_035227
swissprot - P70314
swissprot - Q3UQH0
swissprot - G3UZS0
Ensembl - ENSMUSG00000021506
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pitx1ENSDARG00000116608Danio rerio
 PITX1ENSGALG00000030237Gallus gallus
 PITX1ENSG00000069011Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*ENSMUSG0000002802363
Pitx3 / O35160 / Pituitary homeobox 3 / O75364* / paired like homeodomain 3*ENSMUSG0000002522951
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSMUSG0000002870726
Otx2 / orthodenticle homeobox 2 / P32243*ENSMUSG0000002184824
Prrx2 / paired related homeobox 2 / Q99811*ENSMUSG0000003947624
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*ENSMUSG0000000591723
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*ENSMUSG0000004157822
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*ENSMUSG0000002658622
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*ENSMUSG0000004454216
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*ENSMUSG0000002649715
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*ENSMUSG0000002109515
Gsc2 / goosecoid homeobox 2 / O15499*ENSMUSG0000002273815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR016233  Homeobox protein Pitx/unc30
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014707 branchiomeric skeletal muscle development IMP
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0035137 hindlimb morphogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048625 myoblast fate commitment IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: SpastM1Gri/Spast+
Genetic Background: B6.C-SpastM1Gri

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: SpastM1Gri/Spast+
Genetic Background: B6.C-SpastM1Gri

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm2Sac/Pitx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fastm1Osa/Fastm1Osa,Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000576 clubbed feet "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: SpastM1Gri/Spast+
Genetic Background: B6.C-SpastM1Gri

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fastm1Osa/Fastm1Osa,Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002728 absent tibia "missing the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004349 absent femur "missing the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004575 small limb buds "reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2tm2Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004688 absent ilium "absence of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004689 small ischium bone "reduced size of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004692 small pubic bone "reduced size of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004694 absent patella "absence of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008338 decreased thyrotroph cell number "reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008381 absent gonial bone "absence of the investing bone that normally lies on the surface of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0009524 absent submandibular gland "absence of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009910 bifurcated tongue "tongue is split into two halves at the anterior tip; this is normal in some animals such as reptiles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013169 small hindlimb buds "reduced size of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm2Sac/Pitx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013349 small Rathke s pouch "reduced size of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pitx1tm1Jdr/Pitx1+,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013351 abnormal Rathke s pouch development "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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