Manteia

ENSMUSG00000025229

Mus musculus

Features

Gene ID:	ENSMUSG00000025229

Biological name :	Pitx3

Synonyms :	O35160 / Pituitary homeobox 3 / Pitx3

Possible biological names infered from orthology :	O75364 / paired like homeodomain 3

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	C3
Gene start:	46135685
Gene end:	46148326

Corresponding Affymetrix probe sets:	10468174 (MoGene1.0st) 1449917_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000026259 Ensembl peptide - ENSMUSP00000134563 NCBI entrez gene - 18742 See in Manteia. MGI - MGI:1100498 RefSeq - NM_008852 RefSeq - XM_006526764 RefSeq Peptide - NP_032878 swissprot - G3UZN3 swissprot - O35160 Ensembl - ENSMUSG00000025229

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pitx1	ENSDARG00000116608	Danio rerio
PITX1	ENSGALG00000030237	Gallus gallus
PITX3	ENSG00000107859	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pitx2 / P97474 / paired-like homeodomain transcription factor 2 / Q99697* / paired like homeodomain 2*	ENSMUSG00000028023	57
Pitx1 / P70314 / paired-like homeodomain transcription factor 1 / P78337* / paired like homeodomain 1*	ENSMUSG00000021506	53
Dmbx1 / Q91ZK4 / Diencephalon/mesencephalon homeobox protein 1 / Q8NFW5* / diencephalon/mesencephalon homeobox 1*	ENSMUSG00000028707	26
Prrx2 / paired related homeobox 2 / Q99811*	ENSMUSG00000039476	25
Prrx1 / P63013 / Paired mesoderm homeobox protein 1 / P54821* / paired related homeobox 1*	ENSMUSG00000026586	23
Otx1 / P80205 / Homeobox protein OTX1 / P32242* / orthodenticle homeobox 1*	ENSMUSG00000005917	22
Otx2 / orthodenticle homeobox 2 / P32243*	ENSMUSG00000021848	22
Crx / O54751 / Cone-rod homeobox protein / O43186* / cone-rod homeobox*	ENSMUSG00000041578	21
Prop1 / P97458 / Homeobox protein prophet of Pit-1 / O75360* / PROP paired-like homeobox 1*	ENSMUSG00000044542	17
Gsc2 / goosecoid homeobox 2 / O15499*	ENSMUSG00000022738	16
Gsc / Q02591 / Homeobox protein goosecoid / P56915* / goosecoid homeobox*	ENSMUSG00000021095	16
Mixl1 / Q9WUI0 / Homeobox protein MIXL1 / Q9H2W2* / Mix paired-like homeobox*	ENSMUSG00000026497	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR003654	OAR domain
IPR009057	Homeobox-like domain superfamily
IPR016233	Homeobox protein Pitx/unc30
IPR017970	Homeobox, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002088	lens development in camera-type eye	IMP
biological_process	GO:0002089	lens morphogenesis in camera-type eye	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IDA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0007626	locomotory behavior	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0014014	negative regulation of gliogenesis	IEA
biological_process	GO:0030901	midbrain development	IMP
biological_process	GO:0035902	response to immobilization stress	IEA
biological_process	GO:0042220	response to cocaine	IEA
biological_process	GO:0043278	response to morphine	IEA
biological_process	GO:0043525	positive regulation of neuron apoptotic process	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0048666	neuron development	IMP
biological_process	GO:0050768	negative regulation of neurogenesis	IEA
biological_process	GO:0070306	lens fiber cell differentiation	IMP
biological_process	GO:0071542	dopaminergic neuron differentiation	TAS
biological_process	GO:1904313	response to methamphetamine hydrochloride	IEA
biological_process	GO:1904935	positive regulation of cell proliferation in midbrain	IEA
biological_process	GO:1990792	cellular response to glial cell derived neurotrophic factor	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IMP
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0000897	abnormal midbrain	"malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0001299	abnormal eye distance/ position	"abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0001307	fused cornea/lens	"condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0001363	increased anxiety-related response	"when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0001407	short stride length	"reduced average distance between steps" [J:34193]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: involves: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0001566	hyperphosphatemia	"abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0001951	abnormal breathing	"irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^tm1Ywa/Ednrb⁺ Genetic Background: involves: 129S/SvEvBrd
MP:0002327	abnormal respiratory function	"anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0002738	hyperresponsive to tactile stimuli	"exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0002864	abnormal ocular fundus morphology	"malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0003063	increased coping response	"enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0003078	aphakia	"absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003224	neuron degeneration	"a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0003243	abnormal dopaminergic neuron morphology	"malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0003244	loss of dopaminergic neurons	"loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR Allelic Composition: Pitx3^tm1Mli/Pitx3^tm1Mli Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Pitx3^tm1.1Jdr/Pitx3^tm1.1Jdr Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0003795	abnormal bone structure		Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0003998	decreased thermal nociceptive threshold	"a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0004016	decreased bone mass	"a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0004102	abnormal dorsal striatum morphology	"any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR
MP:0004151	hypoferremia	"less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005102	abnormal iris pigmentation	"anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0005176	eyelids fail to open	"eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005193	abnormal anterior eye segment morphology	"anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0005195	abnormal posterior eye segment morphology	"anomalous structure of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005533	increased body temperature	"greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005545	abnormal lens development	"aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0005573	increased breathing frequency	"greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005586	decreased tidal volume	"less than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0005643	decreased dopamine level	"less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008260	abnormal autophagy	"abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0008493	alpha-synuclein inclusion body	"formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008532	decreased chemical nociceptive threshold	"a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008805	decreased circulating amylase level	"reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008821	increased blood uric acid level	"greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008822	decreased blood uric acid level	"reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0008947	increased neuron number	"greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Pitx3^tm1Mli/Pitx3^tm1Mli Genetic Background: involves: 129P2/OlaHsd
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6 Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0010149	abnormal synaptic dopamine release	"aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^tm1.1Cai/Pitx3⁺,Tg(tetO-SNCAA53T)E2Cai/0 Genetic Background:* involves: 129 * C57BL/6J * FVB/N
MP:0010571	shortened ST segment	"reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Pitx3^{tm1.1(KOMP)Vlcg}/Pitx3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Pitx3^{tm1.1(KOMP)Vlcg}/J
MP:0011448	decreased dopaminergic neuron number	"fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]	Show Allelic Composition: Pitx3^eyl/Pitx3^eyl Genetic Background: involves: C3H/He * C57BL/6
MP:0012101	acoria	"absence of the pupil of the eye" [MGI:anna]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0013219	abnormal substantia nigra pars compacta morphology	"any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]	Show Allelic Composition: Scyl1^mdf/Scyl1^mdf Genetic Background: involves: CFW * C57BL/6J * C57BR
MP:0013453	enlarged lacrimal gland	"increased size of any of the paired glands that secrete the aqueous layer of the tear film" [MGI:Anna]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6
MP:0020543	decreased substantia nigra size	"decreased size of the substantia nigra" [MGI:smb]	Show Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr