ENSDARG00000002510


Danio rerio

Features
Gene ID: ENSDARG00000002510
  
Biological name :dmbx1b
  
Synonyms : diencephalon/mesencephalon homeobox 1b / dmbx1b / Q566X8
  
Possible biological names infered from orthology : diencephalon/mesencephalon homeobox 1 / Diencephalon/mesencephalon homeobox protein 1 / DMBX1 / Q8NFW5 / Q91ZK4
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 3563890
Gene end: 3573716
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000027542
NCBI entrez gene - 550288     See in Manteia.
RefSeq - NM_001017625
RefSeq Peptide - NP_001017625
swissprot - B2GPS4
swissprot - Q566X8
ZFIN ID - ZDB-GENE-050417-97
Ensembl - ENSDARG00000002510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DMBX1ENSGALG00000010436Gallus gallus
 DMBX1ENSG00000197587Homo sapiens
 Dmbx1ENSMUSG00000028707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992274
zgc:101100ENSDARG0000002195927
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619422
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006922
otx5 / orthodenticle homolog 5ENSDARG0000004348321
crx / cone-rod homeoboxENSDARG0000001198921
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123521
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660821
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499219
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397118
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070318
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202717
pax10 / paired box 10ENSDARG0000005336414
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925213
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IGI
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0061074 regulation of neural retina development IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens decreased size , abnormal
Show

 ZFA:0000152 retina retina decreased thickness , abnormal
retina increased amount , abnormal
retina central region increased amount , abnormal
retina peripheral region increased amount , abnormal
retina neuronal stem cell undifferentiated , abnormal
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 ZFA:0000445 optic tectum optic tectum morphology , abnormal
optic tectum decreased size , abnormal
Show

 ZFA:0001114 head head increased amount , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell absent , abnormal
amacrine cell decreased amount , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell absent , abnormal
retinal cone cell decreased amount , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased amount , abnormal
Show

 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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