ENSDARG00000018820


Danio rerio

Features
Gene ID: ENSDARG00000018820
  
Biological name :flncb
  
Synonyms : filamin C, gamma b (actin binding protein 280) / flncb
  
Possible biological names infered from orthology : filamin C / FLNC / Q14315 / Q8VHX6
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 10066840
Gene end: 10130349
  
Corresponding Affymetrix probe sets: Dr.3713.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000024947
NCBI entrez gene - 570288     See in Manteia.
swissprot - F1QL44
ZFIN ID - ZDB-GENE-041008-175
Ensembl - ENSDARG00000018820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FLNCENSG00000128591Homo sapiens
 FlncENSMUSG00000068699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
flnca / filamin C, gamma a (actin binding protein 280) / FLNC* / Q14315* / Q8VHX6* / filamin C*ENSDARG0000001856679
flna / filamin A, alpha (actin binding protein 280) / P21333* / Q8BTM8* / filamin A*ENSDARG0000007420166
CABZ01030862.1ENSDARG0000009837437
flnb / filamin B, beta (actin binding protein 278)ENSDARG0000009228134
syne1b / spectrin repeat containing, nuclear envelope 1b / SYNE1* / Q6ZWR6* / Q8NF91* / spectrin repeat containing nuclear envelope protein 1* / Mus musculus spectrin repeat containing, nuc...ENSDARG0000006306816
syne1a / spectrin repeat containing, nuclear envelope 1a / SYNE1* / Q6ZWR6* / Q8NF91* / spectrin repeat containing nuclear envelope protein 1* / Mus musculus spectrin repeat containing, nuc...ENSDARG0000000949916
si:ch211-207i1.2 / SYNE2* / Q8WXH0* / Q6ZWQ0* / spectrin repeat containing, nuclear envelope 2* / spectrin repeat containing nuclear envelope protein 2*ENSDARG0000003010712
clmn / calmin / Q8C5W0* / Q96JQ2*ENSDARG000000968675
syne2b / spectrin repeat containing, nuclear envelope 2b / SYNE2* / Q8WXH0* / Q6ZWQ0* / spectrin repeat containing, nuclear envelope 2* / spectrin repeat containing nuclear envelope protein 2*ENSDARG000000534844
FP325130.1 / FLNB* / O75369* / filamin B*ENSDARG000001125274
zgc:100997 / CLMN* / calmin* / Q8C5W0* / Q96JQ2*ENSDARG000000436674
si:ch211-137a8.2ENSDARG000000689262
zgc:165653ENSDARG000001047131


Protein motifs (from Interpro)
Interpro ID Name
 IPR001298  Filamin/ABP280 repeat
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR017868  Filamin/ABP280 repeat-like
 IPR032461  Filamin C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0046716 muscle cell cellular homeostasis IMP
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Cell-extracellular matrix interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye malformed , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
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 ZFA:0000217 inner ear inner ear malformed , abnormal
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 ZFA:0000471 atrium atrium hypertrophic , abnormal
atrium cardiac muscle cell increased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
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 ZFA:0001117 post-vent region post-vent region malformed , abnormal
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 ZFA:0001462 somite border somite border myosin complex aggregated , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell broken , abnormal
slow muscle cell quality , abnormal
slow muscle cell non-functional , abnormal
slow muscle cell actin filament irregular spatial pattern , abnormal
slow muscle cell myosin filament irregular spatial pattern , abnormal
slow muscle cell type III intermediate filament irregular spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction






 

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