ENSDARG00000103607


Danio rerio

Features
Gene ID: ENSDARG00000103607
  
Biological name :wtip
  
Synonyms : A8DZE6 / WT1 interacting protein / wtip
  
Possible biological names infered from orthology : A6NIX2 / Q7TQJ8
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 438263
Gene end: 494606
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131477
Ensembl peptide - ENSDARP00000132856
NCBI entrez gene - 566046     See in Manteia.
RefSeq - NM_001123278
RefSeq Peptide - NP_001116750
swissprot - A8DZE6
swissprot - A0A0R4IED4
ZFIN ID - ZDB-GENE-050419-261
Ensembl - ENSDARG00000103607
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WTIPENSGALG00000025864Gallus gallus
 WTIPENSG00000142279Homo sapiens
 WtipENSMUSG00000036459Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ajuba / ajuba LIM protein / Q91XC0* / Q96IF1* / LIM domain-containing protein ajuba *ENSDARG0000007784231
lpp / LIM domain containing preferred translocation partner in lipoma / Q8BFW7* / Q93052* / Lipoma-preferred partner homolog *ENSDARG0000002357820
trip6 / thyroid hormone receptor interactor 6 / Q15654* / Q9Z1Y4*ENSDARG0000006933119
zyx / zyxin / Q15942* / Q62523*ENSDARG0000007573318
CABZ01043952.1 / LIMD1* / Q9UGP4* / LIM domains containing 1*ENSDARG0000011095415
fblim1 / filamin binding LIM protein 1 / Q71FD7* / Q8WUP2*ENSDARG0000007155811
ablim1a / actin binding LIM protein 1a / ABLIM1* / O14639* / Q8K4G5* / actin binding LIM protein 1*ENSDARG0000006014910
ablim3 / actin binding LIM protein family, member 3 / O94929* / Q69ZX8*ENSDARG0000008816810
ablim2 / actin binding LIM protein family, member 2 / Q6H8Q1* / Q8BL65* / actin-binding LIM protein 2*ENSDARG000000552239
ablim1b / actin binding LIM protein 1b / ABLIM1* / O14639* / Q8K4G5* / actin binding LIM protein 1*ENSDARG000000450647
dmtn / dematin actin binding protein / Q08495* / Q9WV69* / Dematin *ENSDARG000000131104
BX465198.3 / DMTN* / Q08495* / dematin actin binding protein*ENSDARG000001164842


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0007010 cytoskeleton organization IBA
 biological_processGO:0014032 neural crest cell development ISS
 biological_processGO:0022604 regulation of cell morphogenesis ISS
 biological_processGO:0035329 hippo signaling IBA
 biological_processGO:0035331 negative regulation of hippo signaling IBA
 biological_processGO:0035844 cloaca development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061032 visceral serous pericardium development IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IBA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005911 cell-cell junction IBA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000115 heart rudiment heart rudiment right side mislocalised , abnormal
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 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm right side mislocalised , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros ciliated cell decreased amount , abnormal
pronephros anterior region dilated , abnormal
pronephros motile cilium immobile , abnormal
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 ZFA:0000330 cloacal chamber cloacal chamber malformed , abnormal
cloacal chamber ciliated cell decreased amount , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal cell morphology , abnormal
atrioventricular canal mislocalised , abnormal
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 ZFA:0001317 endocardial cushion endocardial cushion absent , abnormal
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 ZFA:0001374 atrial myocardium atrial myocardium decreased thickness , abnormal
atrial myocardium separated from ventricular endocardium , abnormal
atrial myocardium separated from ventricular myocardium , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus cystic , abnormal
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 ZFA:0005808 proepicardial cluster proepicardial cluster decreased amount , abnormal
proepicardial cluster ciliary basal body absent , abnormal
Show

 ZFA:0009032 ciliated cell ciliated cell cilium decreased length , abnormal
ciliated cell mitotic spindle increased angle to pronephros apical-basal axis relative to substrate, abnormal
ciliated cell ciliary rootlet absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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