ENSG00000011566


Homo sapiens

Features
Gene ID: ENSG00000011566
  
Biological name :MAP4K3
  
Synonyms : MAP4K3 / mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p22.1
Gene start: 39249266
Gene end: 39437312
  
Corresponding Affymetrix probe sets: 218311_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399228
Ensembl peptide - ENSP00000405137
Ensembl peptide - ENSP00000410183
Ensembl peptide - ENSP00000416958
Ensembl peptide - ENSP00000476533
Ensembl peptide - ENSP00000263881
Ensembl peptide - ENSP00000345434
NCBI entrez gene - 8491     See in Manteia.
OMIM - 604921
RefSeq - NM_003618
RefSeq - NM_001270425
RefSeq Peptide - NP_001257354
RefSeq Peptide - NP_003609
swissprot - V9GY95
swissprot - F5H5A3
swissprot - F8WAZ1
swissprot - F8WBC3
swissprot - H7C1A4
swissprot - Q8IVH8
Ensembl - ENSG00000011566
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map4k3aENSDARG00000087742Danio rerio
 MAP4K3ENSGALG00000039720Gallus gallus
 Map4k3ENSMUSG00000024242Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298366
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806751
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481443
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431031
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105430
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150330
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357224
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561322
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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