ENSMUSG00000024242


Mus musculus

Features
Gene ID: ENSMUSG00000024242
  
Biological name :Map4k3
  
Synonyms : Map4k3 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q99JP0
  
Possible biological names infered from orthology : Q8IVH8
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E3
Gene start: 80580512
Gene end: 80728093
  
Corresponding Affymetrix probe sets: 10453178 (MoGene1.0st)   1426759_at (Mouse Genome 430 2.0 Array)   1446798_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025089
Ensembl peptide - ENSMUSP00000108008
NCBI entrez gene - 225028     See in Manteia.
MGI - MGI:2154405
RefSeq - XM_006524199
RefSeq - NM_001290345
RefSeq - XM_006524196
RefSeq - XM_006524197
RefSeq - XM_006524198
RefSeq - XM_006524192
RefSeq - XM_006524194
RefSeq - XM_006524195
RefSeq Peptide - NP_001277274
swissprot - Q99JP0
swissprot - E9QNE9
Ensembl - ENSMUSG00000024242
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map4k3aENSDARG00000087742Danio rerio
 MAP4K3ENSGALG00000039720Gallus gallus
 MAP4K3ENSG00000011566Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476166
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494850
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733744
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769231
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607431
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082730
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285423
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506023
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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