ENSMUSG00000024948


Mus musculus

Features
Gene ID: ENSMUSG00000024948
  
Biological name :Map4k2
  
Synonyms : Map4k2 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q61161
  
Possible biological names infered from orthology : Q12851
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6341135
Gene end: 6355615
  
Corresponding Affymetrix probe sets: 10460891 (MoGene1.0st)   1428297_at (Mouse Genome 430 2.0 Array)   1434833_at (Mouse Genome 430 2.0 Array)   1450244_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120123
Ensembl peptide - ENSMUSP00000115741
Ensembl peptide - ENSMUSP00000121375
Ensembl peptide - ENSMUSP00000121856
Ensembl peptide - ENSMUSP00000025897
Ensembl peptide - ENSMUSP00000114243
NCBI entrez gene - 26412     See in Manteia.
MGI - MGI:1346883
RefSeq - XM_017318212
RefSeq - NM_009006
RefSeq - XM_006531755
RefSeq - XM_006531756
RefSeq - XM_006531757
RefSeq - XM_006531758
RefSeq - XM_006531760
RefSeq - XM_017318211
RefSeq - NM_001291787
RefSeq Peptide - NP_001278716
RefSeq Peptide - NP_033032
swissprot - D6RCZ7
swissprot - D6RG51
swissprot - D3YUH9
swissprot - Q61161
swissprot - F6RPB0
Ensembl - ENSMUSG00000024948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map4k2ENSDARG00000001234Danio rerio
 map4k6ENSDARG00000033444Danio rerio
 MAP4K2ENSG00000168067Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424255
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476153
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733741
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082729
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769229
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607429
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506021
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285421
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006903 vesicle targeting IDA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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