ENSMUSG00000027692


Mus musculus

Features
Gene ID: ENSMUSG00000027692
  
Biological name :Tnik
  
Synonyms : P83510 / Tnik / TRAF2 and NCK interacting kinase
  
Possible biological names infered from orthology : Q9UKE5
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 28263214
Gene end: 28675858
  
Corresponding Affymetrix probe sets: 10491136 (MoGene1.0st)   1429870_at (Mouse Genome 430 2.0 Array)   1430579_at (Mouse Genome 430 2.0 Array)   1455256_at (Mouse Genome 430 2.0 Array)   1458403_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123859
Ensembl peptide - ENSMUSP00000125466
Ensembl peptide - ENSMUSP00000125411
Ensembl peptide - ENSMUSP00000125081
Ensembl peptide - ENSMUSP00000124876
Ensembl peptide - ENSMUSP00000124726
Ensembl peptide - ENSMUSP00000124681
Ensembl peptide - ENSMUSP00000124387
Ensembl peptide - ENSMUSP00000124011
NCBI entrez gene - 665113     See in Manteia.
MGI - MGI:1916264
RefSeq - XM_011249705
RefSeq - NM_001163007
RefSeq - NM_001163008
RefSeq - NM_001163009
RefSeq - NM_026910
RefSeq - XM_006535517
RefSeq - XM_006535518
RefSeq - XM_006535519
RefSeq - XM_006535520
RefSeq - XM_006535521
RefSeq - XM_011249704
RefSeq Peptide - NP_001156479
RefSeq Peptide - NP_001156481
RefSeq Peptide - NP_081186
RefSeq Peptide - NP_001156480
swissprot - E0CXD6
swissprot - B9EKN8
swissprot - B2RQ80
swissprot - E0CZF8
swissprot - E9PUL9
swissprot - P83510
swissprot - E0CZD7
swissprot - E0CYV5
swissprot - E0CY98
Ensembl - ENSMUSG00000027692
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnikaENSDARG00000056218Danio rerio
 tnikbENSDARG00000009031Danio rerio
 TNIKENSGALG00000009298Gallus gallus
 TNIKENSG00000154310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082766
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607465
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285430
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424221
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476119
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733718
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494817
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506017
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030033 microvillus assembly IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0012424 decreased alimentary system tumor incidence "less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [MGI:csmith]
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Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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