ENSMUSG00000037337


Mus musculus

Features
Gene ID: ENSMUSG00000037337
  
Biological name :Map4k1
  
Synonyms : Map4k1 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / P70218
  
Possible biological names infered from orthology : mitogen-activated protein kinase kinase kinase kinase 1 / Q92918
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 28982050
Gene end: 29003279
  
Corresponding Affymetrix probe sets: 10551666 (MoGene1.0st)   1439323_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082995
Ensembl peptide - ENSMUSP00000146807
Ensembl peptide - ENSMUSP00000147189
NCBI entrez gene - 26411     See in Manteia.
MGI - MGI:1346882
RefSeq - XM_017322280
RefSeq - NM_001355054
RefSeq - NM_008279
RefSeq - XM_006539996
RefSeq - XM_006539997
RefSeq - XM_006539998
RefSeq - XM_006539999
RefSeq - XM_006540000
RefSeq - XM_006539995
RefSeq Peptide - NP_001341983
RefSeq Peptide - NP_032305
swissprot - P70218
swissprot - Q3UPT4
swissprot - A0A140LJF0
Ensembl - ENSMUSG00000037337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01099833.1ENSDARG00000114026Danio rerio
 MAP4K1ENSG00000104814Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424248
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476145
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494841
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082731
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607430
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769229
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285423
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506021
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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