ENSMUSG00000026074


Mus musculus

Features
Gene ID: ENSMUSG00000026074
  
Biological name :Map4k4
  
Synonyms : Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4
  
Possible biological names infered from orthology : O95819
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 39900913
Gene end: 40026310
  
Corresponding Affymetrix probe sets: 10345715 (MoGene1.0st)   1422615_at (Mouse Genome 430 2.0 Array)   1434184_s_at (Mouse Genome 430 2.0 Array)   1440609_at (Mouse Genome 430 2.0 Array)   1448050_s_at (Mouse Genome 430 2.0 Array)   1459912_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129796
Ensembl peptide - ENSMUSP00000126961
Ensembl peptide - ENSMUSP00000141235
Ensembl peptide - ENSMUSP00000142056
Ensembl peptide - ENSMUSP00000141956
Ensembl peptide - ENSMUSP00000141862
Ensembl peptide - ENSMUSP00000141665
Ensembl peptide - ENSMUSP00000141613
Ensembl peptide - ENSMUSP00000141573
Ensembl peptide - ENSMUSP00000141400
Ensembl peptide - ENSMUSP00000141332
NCBI entrez gene - 26921     See in Manteia.
MGI - MGI:1349394
RefSeq - XM_017321021
RefSeq - XM_006496043
RefSeq - XM_006496044
RefSeq - XM_006496045
RefSeq - XM_006496046
RefSeq - XM_011238530
RefSeq - XM_017320994
RefSeq - XM_017320998
RefSeq - XM_017321001
RefSeq - XM_017321002
RefSeq - XM_017321004
RefSeq - XM_017321010
RefSeq - XM_017321011
RefSeq - XM_017321013
RefSeq - XM_017321016
RefSeq - XM_017321018
RefSeq - NM_001252200
RefSeq - NM_001252201
RefSeq - NM_001252202
RefSeq - NM_008696
RefSeq - XM_006496041
RefSeq - XM_006496042
RefSeq Peptide - NP_001239131
RefSeq Peptide - NP_032722
RefSeq Peptide - NP_001239130
RefSeq Peptide - NP_001239129
swissprot - A0A0A6YWR8
swissprot - A0A0A6YWM8
swissprot - A0A0A6YWJ2
swissprot - E9PVG7
swissprot - F8VPL5
swissprot - A0A0A6YVZ8
swissprot - A0A0A6YVR7
swissprot - A0A0A6YW53
swissprot - B7ZNR9
swissprot - B2RUE8
swissprot - A0A0A6YXE5
Ensembl - ENSMUSG00000026074
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map4k4ENSDARG00000098670Danio rerio
 MAP4K4ENSGALG00000016781Gallus gallus
 MAP4K4ENSG00000071054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769269
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082765
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285431
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424221
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476120
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733719
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494818
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027217
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070571 negative regulation of neuron projection regeneration IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004111 creatine kinase activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0012739 abnormal anterior primitive streak morphology "any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [MGI:anna]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr