ENSMUSG00000052854


Mus musculus

Features
Gene ID: ENSMUSG00000052854
  
Biological name :Nrk
  
Synonyms : Nik-related protein kinase / Nrk / Q9R0G8
  
Possible biological names infered from orthology : Nik related kinase / Q7Z2Y5
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F1
Gene start: 138914430
Gene end: 139010532
  
Corresponding Affymetrix probe sets: 10601942 (MoGene1.0st)   1436399_s_at (Mouse Genome 430 2.0 Array)   1450078_at (Mouse Genome 430 2.0 Array)   1450079_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063397
Ensembl peptide - ENSMUSP00000115962
Ensembl peptide - ENSMUSP00000108675
NCBI entrez gene - 27206     See in Manteia.
MGI - MGI:1351326
RefSeq - NM_013724
RefSeq - XM_006528550
RefSeq Peptide - NP_038752
swissprot - D6RFR0
swissprot - Q9R0G8
swissprot - B1B0C9
Ensembl - ENSMUSG00000052854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:zfos-2326c3.2ENSDARG00000098680Danio rerio
 NRKENSGALG00000008970Gallus gallus
 NRKENSG00000123572Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769228
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607428
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082727
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476114
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424214
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506013
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733713
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494812
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007256 activation of JNKK activity IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007567 parturition IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0060721 regulation of spongiotrophoblast cell proliferation IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nrktm1Mkom/Y
Genetic Background: B6.129S4-Nrktm1Mkom

 MP:0004514 dystocia "slow or difficult delivery of offspring and/or placenta" [MESH:C13.703.420.288]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004920 increased placenta weight "increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nrktm1Mkom/Y
Genetic Background: B6.129S4-Nrktm1Mkom

Allelic Composition: Nrktm1Mkom/Nrk+
Genetic Background: B6.129S4-Nrktm1Mkom

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nrktm1Mkom/Y
Genetic Background: B6.129S4-Nrktm1Mkom

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nrktm1Mkom/Y
Genetic Background: B6.129S4-Nrktm1Mkom

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nrktm1Mkom/Y
Genetic Background: B6.129S4-Nrktm1Mkom

Allelic Composition: Nrktm1Mkom/Nrk+
Genetic Background: B6.129S4-Nrktm1Mkom

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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