ENSMUSG00000025060


Mus musculus

Features
Gene ID: ENSMUSG00000025060
  
Biological name :Slk
  
Synonyms : O54988 / Slk / STE20-like serine/threonine-protein kinase
  
Possible biological names infered from orthology : Q9H2G2 / STE20 like kinase
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 47579678
Gene end: 47645246
  
Corresponding Affymetrix probe sets: 10463803 (MoGene1.0st)   1419092_a_at (Mouse Genome 430 2.0 Array)   1425977_a_at (Mouse Genome 430 2.0 Array)   1433999_at (Mouse Genome 430 2.0 Array)   1443815_x_at (Mouse Genome 430 2.0 Array)   1449336_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026043
Ensembl peptide - ENSMUSP00000049977
NCBI entrez gene - 20874     See in Manteia.
MGI - MGI:103241
RefSeq - XM_006526827
RefSeq - NM_001164639
RefSeq - NM_009289
RefSeq Peptide - NP_001158111
RefSeq Peptide - NP_033315
swissprot - O54988
swissprot - A2RRK3
Ensembl - ENSMUSG00000025060
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slkaENSDARG00000061525Danio rerio
 SLKENSGALG00000008318Gallus gallus
 SLKENSG00000065613Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stk10 / O55098 / Serine/threonine-protein kinase 10 / O94804* / serine/threonine kinase 10*ENSMUSG0000002027245
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082718
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769218
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607418
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424216
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285416
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476115
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494814
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001943  UVR domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022165  Polo kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0031122 cytoplasmic microtubule organization IEA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000962 disorganized dorsal root ganglia "loss of segmentation pattern of DRGs; loss of regular spacing " [J:62022, J:62023]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008957 abnormal placenta junctional zone morphology "fetally derived placental region that separates the maternal uterine tissue from the placenta labyrinth" [PMID:16367805]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0009658 increased placenta apoptosis "increase in the number of cells of the placenta undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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