ENSG00000065613


Homo sapiens

Features
Gene ID: ENSG00000065613
  
Biological name :SLK
  
Synonyms : Q9H2G2 / SLK / STE20 like kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.33
Gene start: 103967201
Gene end: 104029233
  
Corresponding Affymetrix probe sets: 206874_s_at (Human Genome U133 Plus 2.0 Array)   206875_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000336824
Ensembl peptide - ENSP00000358770
NCBI entrez gene - 9748     See in Manteia.
OMIM - 616563
RefSeq - XM_011540401
RefSeq - NM_001304743
RefSeq - NM_014720
RefSeq Peptide - NP_055535
RefSeq Peptide - NP_001291672
swissprot - Q9H2G2
Ensembl - ENSG00000065613
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slkaENSDARG00000061525Danio rerio
 SLKENSGALG00000008318Gallus gallus
 SlkENSMUSG00000025060Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278645
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150319
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431019
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105418
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357217
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156616
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298315
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806715
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001943  UVR domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022165  Polo kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0031122 cytoplasmic microtubule organization IMP
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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