ENSG00000072786


Homo sapiens

Features
Gene ID: ENSG00000072786
  
Biological name :STK10
  
Synonyms : O94804 / serine/threonine kinase 10 / STK10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.1
Gene start: 172042073
Gene end: 172188386
  
Corresponding Affymetrix probe sets: 203047_at (Human Genome U133 Plus 2.0 Array)   228394_at (Human Genome U133 Plus 2.0 Array)   40420_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000176763
Ensembl peptide - ENSP00000428806
NCBI entrez gene - 6793     See in Manteia.
OMIM - 603919
RefSeq - XM_017009788
RefSeq - NM_005990
RefSeq Peptide - NP_005981
swissprot - O94804
swissprot - H0YB71
Ensembl - ENSG00000072786
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk10ENSDARG00000101894Danio rerio
 STK10ENSGALG00000002816Gallus gallus
 Stk10ENSMUSG00000020272Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561357
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431023
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105422
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150322
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156620
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806718
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481418
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298318
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357218


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022165  Polo kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0071593 lymphocyte aggregation IEA
 biological_processGO:2000401 regulation of lymphocyte migration IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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