ENSG00000154310


Homo sapiens

Features
Gene ID: ENSG00000154310
  
Biological name :TNIK
  
Synonyms : Q9UKE5 / TNIK / TRAF2 and NCK interacting kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q26.31
Gene start: 171061339
Gene end: 171460408
  
Corresponding Affymetrix probe sets: 211828_s_at (Human Genome U133 Plus 2.0 Array)   213107_at (Human Genome U133 Plus 2.0 Array)   213109_at (Human Genome U133 Plus 2.0 Array)   239288_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418916
Ensembl peptide - ENSP00000418378
Ensembl peptide - ENSP00000419308
Ensembl peptide - ENSP00000419990
Ensembl peptide - ENSP00000284483
Ensembl peptide - ENSP00000345352
Ensembl peptide - ENSP00000349880
Ensembl peptide - ENSP00000399511
Ensembl peptide - ENSP00000417338
Ensembl peptide - ENSP00000418156
NCBI entrez gene - 23043     See in Manteia.
OMIM - 610005
RefSeq - NM_001161561
RefSeq - NM_001161560
RefSeq - NM_001161562
RefSeq - NM_001161563
RefSeq - NM_001161564
RefSeq - NM_001161565
RefSeq - NM_001161566
RefSeq - NM_015028
RefSeq Peptide - NP_001155038
RefSeq Peptide - NP_001155036
RefSeq Peptide - NP_001155037
RefSeq Peptide - NP_055843
RefSeq Peptide - NP_001155032
RefSeq Peptide - NP_001155033
RefSeq Peptide - NP_001155034
RefSeq Peptide - NP_001155035
swissprot - Q9UKE5
swissprot - C9JVV1
swissprot - C9J338
Ensembl - ENSG00000154310
  
Related genetic diseases (OMIM): 617028 - Mental retardation, autosomal recessive 54, 617028
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnikaENSDARG00000056218Danio rerio
 tnikbENSDARG00000009031Danio rerio
 TNIKENSGALG00000009298Gallus gallus
 TnikENSMUSG00000027692Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150365
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105465
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357234
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156620
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298319
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481418
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806718
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561317
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007256 activation of JNKK activity IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030033 microvillus assembly IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048814 regulation of dendrite morphogenesis IDA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000750 Impaired language development 
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 HP:0000752 Hyperactivity 
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 HP:0001249 Mental retardation 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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