ENSG00000104814


Homo sapiens

Features
Gene ID: ENSG00000104814
  
Biological name :MAP4K1
  
Synonyms : MAP4K1 / mitogen-activated protein kinase kinase kinase kinase 1 / Q92918
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 38587641
Gene end: 38618882
  
Corresponding Affymetrix probe sets: 206296_x_at (Human Genome U133 Plus 2.0 Array)   214219_x_at (Human Genome U133 Plus 2.0 Array)   214339_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468396
Ensembl peptide - ENSP00000465774
Ensembl peptide - ENSP00000468164
Ensembl peptide - ENSP00000380066
Ensembl peptide - ENSP00000465039
Ensembl peptide - ENSP00000465303
NCBI entrez gene - 11184     See in Manteia.
OMIM - 601983
RefSeq - XM_017026231
RefSeq - NM_001042600
RefSeq - NM_007181
RefSeq - XM_011526403
RefSeq - XM_011526404
RefSeq Peptide - NP_001036065
RefSeq Peptide - NP_009112
swissprot - K7ER95
swissprot - K7ERT2
swissprot - Q92918
swissprot - K7EKT6
swissprot - K7EJS6
Ensembl - ENSG00000104814
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01099833.1ENSDARG00000114026Danio rerio
 Map4k1ENSMUSG00000037337Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156646
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298345
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806741
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150330
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431029
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105429
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357223
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278621
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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