ENSG00000168067


Homo sapiens

Features
Gene ID: ENSG00000168067
  
Biological name :MAP4K2
  
Synonyms : MAP4K2 / mitogen-activated protein kinase kinase kinase kinase 2 / Q12851
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 64784914
Gene end: 64803241
  
Corresponding Affymetrix probe sets: 204936_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403563
Ensembl peptide - ENSP00000403410
Ensembl peptide - ENSP00000404534
Ensembl peptide - ENSP00000413167
Ensembl peptide - ENSP00000294066
Ensembl peptide - ENSP00000366567
Ensembl peptide - ENSP00000400594
NCBI entrez gene - 5871     See in Manteia.
OMIM - 603166
RefSeq - XM_017018096
RefSeq - NM_001307990
RefSeq - NM_004579
RefSeq - XM_011545203
RefSeq - XM_011545204
RefSeq - XM_017018093
RefSeq - XM_017018094
RefSeq - XM_017018095
RefSeq Peptide - NP_004570
RefSeq Peptide - NP_001294919
swissprot - F2Z2B3
swissprot - F8WCP4
swissprot - H7C208
swissprot - Q12851
swissprot - A0A024R567
swissprot - C9JCU6
Ensembl - ENSG00000168067
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map4k2ENSDARG00000001234Danio rerio
 map4k6ENSDARG00000033444Danio rerio
 Map4k2ENSMUSG00000024948Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156655
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298353
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481441
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150330
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105429
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431029
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357223
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561322
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006903 vesicle targeting IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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