ENSG00000141503


Homo sapiens

Features
Gene ID: ENSG00000141503
  
Biological name :MINK1
  
Synonyms : MINK1 / misshapen like kinase 1 / Q8N4C8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.2
Gene start: 4833388
Gene end: 4898061
  
Corresponding Affymetrix probe sets: 209241_x_at (Human Genome U133 Plus 2.0 Array)   214246_x_at (Human Genome U133 Plus 2.0 Array)   214625_s_at (Human Genome U133 Plus 2.0 Array)   215909_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461500
Ensembl peptide - ENSP00000459269
Ensembl peptide - ENSP00000459699
Ensembl peptide - ENSP00000269296
Ensembl peptide - ENSP00000347427
Ensembl peptide - ENSP00000406487
Ensembl peptide - ENSP00000459102
NCBI entrez gene - 50488     See in Manteia.
OMIM - 609426
RefSeq - XM_017024708
RefSeq - NM_153827
RefSeq - NM_170663
RefSeq - XM_006721531
RefSeq - XM_006721532
RefSeq - XM_006721536
RefSeq - XM_011523906
RefSeq - XM_017024704
RefSeq - XM_017024705
RefSeq - XM_017024706
RefSeq - XM_017024707
RefSeq - NM_001024937
RefSeq - NM_001321236
RefSeq - NM_015716
RefSeq Peptide - NP_001308165
RefSeq Peptide - NP_056531
RefSeq Peptide - NP_722549
RefSeq Peptide - NP_733763
RefSeq Peptide - NP_001020108
swissprot - I3L203
swissprot - I3L2I2
swissprot - I3L4T2
swissprot - Q8N4C8
swissprot - I3L1U1
Ensembl - ENSG00000141503
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mink1ENSDARG00000035360Danio rerio
 Mink1ENSMUSG00000020827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431066
MAP4K4 / O95819 / mitogen-activated protein kinase kinase kinase kinase 4ENSG0000007105462
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357234
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298320
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156620
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481419
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806718
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561317
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0001952 regulation of cell-matrix adhesion IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007268 chemical synaptic transmission ISS
 biological_processGO:0007275 multicellular organism development ISS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0048813 dendrite morphogenesis ISS
 biological_processGO:1900745 positive regulation of p38MAPK cascade ISS
 biological_processGO:2000311 regulation of AMPA receptor activity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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