ENSMUSG00000020272


Mus musculus

Features
Gene ID: ENSMUSG00000020272
  
Biological name :Stk10
  
Synonyms : O55098 / Serine/threonine-protein kinase 10 / Stk10
  
Possible biological names infered from orthology : O94804 / serine/threonine kinase 10
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 32533305
Gene end: 32624587
  
Corresponding Affymetrix probe sets: 10375083 (MoGene1.0st)   1417751_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099885
NCBI entrez gene - 20868     See in Manteia.
MGI - MGI:1099439
RefSeq - NM_009288
RefSeq - XM_017314404
RefSeq Peptide - NP_033314
swissprot - O55098
Ensembl - ENSMUSG00000020272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk10ENSDARG00000101894Danio rerio
 STK10ENSGALG00000002816Gallus gallus
 STK10ENSG00000072786Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slk / O54988 / STE20-like serine/threonine-protein kinase / Q9H2G2* / STE20 like kinase*ENSMUSG0000002506057
Tnik / P83510 / TRAF2 and NCK interacting kinase / Q9UKE5*ENSMUSG0000002769223
Map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSMUSG0000002607422
Mink1 / Q9JM52 / misshapen-like kinase 1 (zebrafish) / Q8N4C8* / misshapen like kinase 1*ENSMUSG0000002082721
Map4k3 / Q99JP0 / Mitogen-activated protein kinase kinase kinase kinase 3 / Q8IVH8*ENSMUSG0000002424219
Map4k5 / Q8BPM2 / Mitogen-activated protein kinase kinase kinase kinase 5 ENSMUSG0000003476118
Map4k1 / P70218 / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 2, mRNA. / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1*ENSMUSG0000003733717
Map4k2 / Q61161 / Mitogen-activated protein kinase kinase kinase kinase 2 / Q12851*ENSMUSG0000002494817
Nrk / Q9R0G8 / Nik-related protein kinase / Q7Z2Y5* / Nik related kinase*ENSMUSG0000005285417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022165  Polo kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0071593 lymphocyte aggregation IMP
 biological_processGO:2000401 regulation of lymphocyte migration IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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