ENSG00000049323


Homo sapiens

Features
Gene ID: ENSG00000049323
  
Biological name :LTBP1
  
Synonyms : latent transforming growth factor beta binding protein 1 / LTBP1 / Q14766
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p22.3
Gene start: 32946972
Gene end: 33399509
  
Corresponding Affymetrix probe sets: 202728_s_at (Human Genome U133 Plus 2.0 Array)   202729_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395211
Ensembl peptide - ENSP00000393057
Ensembl peptide - ENSP00000405993
Ensembl peptide - ENSP00000417591
Ensembl peptide - ENSP00000415412
Ensembl peptide - ENSP00000384091
Ensembl peptide - ENSP00000384373
Ensembl peptide - ENSP00000385359
Ensembl peptide - ENSP00000386043
Ensembl peptide - ENSP00000388154
NCBI entrez gene - 4052     See in Manteia.
OMIM - 150390
RefSeq - XM_017004110
RefSeq - XM_005264317
RefSeq - XM_005264318
RefSeq - XM_011532853
RefSeq - XM_011532855
RefSeq - XM_011532856
RefSeq - XM_011532857
RefSeq - XM_011532858
RefSeq - XM_011532859
RefSeq - XM_011532860
RefSeq - XM_011532861
RefSeq - XM_011532862
RefSeq - XM_017004108
RefSeq - XM_017004109
RefSeq - NM_000627
RefSeq - NM_001166264
RefSeq - NM_001166265
RefSeq - NM_001166266
RefSeq - NM_206943
RefSeq Peptide - NP_001159736
RefSeq Peptide - NP_001159737
RefSeq Peptide - NP_001159738
RefSeq Peptide - NP_996826
RefSeq Peptide - NP_000618
swissprot - H7C4L5
swissprot - Q14766
swissprot - C9JD84
swissprot - E7EV71
swissprot - C9JDW2
swissprot - H7BZ76
swissprot - H7C0I7
swissprot - H7C2H7
Ensembl - ENSG00000049323
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ltbp1ENSDARG00000056922Danio rerio
 LTBP1ENSGALG00000010448Gallus gallus
 Ltbp1ENSMUSG00000001870Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LTBP2 / Q14767 / latent transforming growth factor beta binding protein 2ENSG0000011968141
LTBP4 / Q8N2S1 / latent transforming growth factor beta binding protein 4ENSG0000009000633
LTBP3 / Q9NS15 / latent transforming growth factor beta binding protein 3ENSG0000016805631
FBN3 / Q75N90 / fibrillin 3ENSG0000014244928
FBN2 / P35556 / fibrillin 2ENSG0000013882928
FBN1 / P35555 / fibrillin 1ENSG0000016614727
FBLN2 / P98095 / fibulin 2ENSG0000016352016
FBLN1 / P23142 / fibulin 1ENSG0000007794211
EFEMP2 / O95967 / EGF containing fibulin extracellular matrix protein 2ENSG000001726386
EFEMP1 / Q12805 / EGF containing fibulin extracellular matrix protein 1ENSG000001153806
FBLN5 / Q9UBX5 / fibulin 5ENSG000001400926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017878  TB domain
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0035583 sequestering of TGFbeta in extracellular matrix TAS
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0060976 coronary vasculature development IEA
 cellular_componentGO:0001527 microfibril IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity NAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IPI
 molecular_functionGO:0050436 microfibril binding IDA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / complex / reaction
 ENSG00000119699 TGFB3 / P10600 / transforming growth factor beta 3  / reaction / complex
 ENSG00000092969 TGFB2 / P61812 / transforming growth factor beta 2  / complex / reaction
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / reaction / complex






 

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