ENSG00000117448


Homo sapiens

Features
Gene ID: ENSG00000117448
  
Biological name :AKR1A1
  
Synonyms : AKR1A1 / aldo-keto reductase family 1 member A1 / P14550
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.1
Gene start: 45550543
Gene end: 45570049
  
Corresponding Affymetrix probe sets: 201900_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476978
Ensembl peptide - ENSP00000312606
Ensembl peptide - ENSP00000361140
Ensembl peptide - ENSP00000398414
Ensembl peptide - ENSP00000480713
Ensembl peptide - ENSP00000476713
NCBI entrez gene - 10327     See in Manteia.
OMIM - 103830
RefSeq - XM_011540492
RefSeq - NM_001202413
RefSeq - NM_001202414
RefSeq - NM_006066
RefSeq - NM_153326
RefSeq - XM_011540491
RefSeq Peptide - NP_006057
RefSeq Peptide - NP_697021
RefSeq Peptide - NP_001189342
RefSeq Peptide - NP_001189343
swissprot - V9GYG2
swissprot - V9GYP9
swissprot - V9HWI0
swissprot - P14550
swissprot - Q5T621
Ensembl - ENSG00000117448
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akr1a1bENSDARG00000052030Danio rerio
 AKR1A1ENSGALG00000010244Gallus gallus
 Akr1a1ENSMUSG00000028692Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60218 / AKR1B10 / aldo-keto reductase family 1 member B10ENSG0000019807450
AKR1B1 / P15121 / aldo-keto reductase family 1 member BENSG0000008566250
C9JRZ8 / AKR1B15 / aldo-keto reductase family 1 member B15ENSG0000022747145
AKR1D1 / P51857 / aldo-keto reductase family 1 member D1ENSG0000012278743
AKR1C1 / Q04828 / aldo-keto reductase family 1 member C1ENSG0000018713442
AKR1E2 / Q96JD6 / aldo-keto reductase family 1 member E2ENSG0000016556842
AKR1C2 / P52895 / aldo-keto reductase family 1 member C2ENSG0000015163242
AKR1C4 / P17516 / aldo-keto reductase family 1 member C4ENSG0000019861041
AKR1C3 / P42330 / aldo-keto reductase family 1 member C3ENSG0000019613939


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0006081 cellular aldehyde metabolic process TAS
 biological_processGO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS
 biological_processGO:0019853 L-ascorbic acid biosynthetic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042840 D-glucuronate catabolic process IEA
 biological_processGO:0046185 aldehyde catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity TAS
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008106 alcohol dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047939 L-glucuronate reductase activity EXP


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Formation of xylulose-5-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr