ENSG00000085662


Homo sapiens

Features
Gene ID: ENSG00000085662
  
Biological name :AKR1B1
  
Synonyms : AKR1B1 / aldo-keto reductase family 1 member B / P15121
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q33
Gene start: 134442350
Gene end: 134459284
  
Corresponding Affymetrix probe sets: 201272_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000285930
Ensembl peptide - ENSP00000414399
Ensembl peptide - ENSP00000413205
NCBI entrez gene - 231     See in Manteia.
OMIM - 103880
RefSeq - NM_001628
RefSeq - XM_005250234
RefSeq Peptide - NP_001619
swissprot - A0A024R7A8
swissprot - E9PEF9
swissprot - P15121
swissprot - E9PCX2
Ensembl - ENSG00000085662
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akr1b1ENSDARG00000006215Danio rerio
 si:dkey-180p18.9ENSDARG00000045598Danio rerio
 Akr1b3ENSMUSG00000001642Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60218 / AKR1B10 / aldo-keto reductase family 1 member B10ENSG0000019807471
C9JRZ8 / AKR1B15 / aldo-keto reductase family 1 member B15ENSG0000022747165
AKR1E2 / Q96JD6 / aldo-keto reductase family 1 member E2ENSG0000016556857
AKR1A1 / P14550 / aldo-keto reductase family 1 member A1ENSG0000011744851
AKR1D1 / P51857 / aldo-keto reductase family 1 member D1ENSG0000012278750
AKR1C2 / P52895 / aldo-keto reductase family 1 member C2ENSG0000015163249
AKR1C1 / Q04828 / aldo-keto reductase family 1 member C1ENSG0000018713449
AKR1C3 / P42330 / aldo-keto reductase family 1 member C3ENSG0000019613948
AKR1C4 / P17516 / aldo-keto reductase family 1 member C4ENSG0000019861048


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0003091 renal water homeostasis IEA
 biological_processGO:0005975 carbohydrate metabolic process TAS
 biological_processGO:0005996 monosaccharide metabolic process IEA
 biological_processGO:0006061 sorbitol biosynthetic process IEA
 biological_processGO:0006700 C21-steroid hormone biosynthetic process TAS
 biological_processGO:0009414 response to water deprivation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0018931 naphthalene metabolic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IEA
 biological_processGO:0035809 regulation of urine volume IEA
 biological_processGO:0042415 norepinephrine metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044597 daunorubicin metabolic process IMP
 biological_processGO:0044598 doxorubicin metabolic process IMP
 biological_processGO:0046370 fructose biosynthetic process TAS
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071475 cellular hyperosmotic salinity response IDA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072061 inner medullary collecting duct development IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0097238 cellular response to methylglyoxal IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032838 plasma membrane bounded cell projection cytoplasm IEA
 cellular_componentGO:0033010 paranodal junction IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097454 Schwann cell microvillus IEA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity EXP
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0043795 glyceraldehyde oxidoreductase activity IDA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis
Fructose biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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