ENSG00000196139


Homo sapiens

Features
Gene ID: ENSG00000196139
  
Biological name :AKR1C3
  
Synonyms : AKR1C3 / aldo-keto reductase family 1 member C3 / P42330
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.1
Gene start: 5035354
Gene end: 5107686
  
Corresponding Affymetrix probe sets: 209160_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474882
Ensembl peptide - ENSP00000369927
Ensembl peptide - ENSP00000401327
Ensembl peptide - ENSP00000474188
NCBI entrez gene - 8644     See in Manteia.
OMIM - 603966
RefSeq - NM_001253908
RefSeq - NM_003739
RefSeq Peptide - NP_001240837
RefSeq Peptide - NP_003730
swissprot - S4R3Z2
swissprot - P42330
swissprot - S4R3D5
swissprot - A0A0A0MSS8
Ensembl - ENSG00000196139
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Akr1c12ENSMUSG00000021211Mus musculus
 Akr1c14ENSMUSG00000033715Mus musculus
 Akr1c19ENSMUSG00000071551Mus musculus
 Akr1c20ENSMUSG00000054757Mus musculus
 Akr1c6ENSMUSG00000021210Mus musculus
 Akr1clENSMUSG00000025955Mus musculus
 Q8K023ENSMUSG00000021214Mus musculus
 Q8VC28ENSMUSG00000021213Mus musculus
 Q91WR5ENSMUSG00000021207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKR1C1 / Q04828 / aldo-keto reductase family 1 member C1ENSG0000018713488
AKR1C2 / P52895 / aldo-keto reductase family 1 member C2ENSG0000015163287
AKR1C4 / P17516 / aldo-keto reductase family 1 member C4ENSG0000019861084
AKR1D1 / P51857 / aldo-keto reductase family 1 member D1ENSG0000012278756
AKR1B1 / P15121 / aldo-keto reductase family 1 member BENSG0000008566247
O60218 / AKR1B10 / aldo-keto reductase family 1 member B10ENSG0000019807446
C9JRZ8 / AKR1B15 / aldo-keto reductase family 1 member B15ENSG0000022747143
AKR1E2 / Q96JD6 / aldo-keto reductase family 1 member E2ENSG0000016556843
AKR1A1 / P14550 / aldo-keto reductase family 1 member A1ENSG0000011744839


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006693 prostaglandin metabolic process TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007584 response to nutrient IEP
 biological_processGO:0008202 steroid metabolic process IEP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IEP
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0010942 positive regulation of cell death IDA
 biological_processGO:0016488 farnesol catabolic process IDA
 biological_processGO:0019371 cyclooxygenase pathway TAS
 biological_processGO:0030216 keratinocyte differentiation IEP
 biological_processGO:0034614 cellular response to reactive oxygen species IDA
 biological_processGO:0042448 progesterone metabolic process IDA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042574 retinal metabolic process IDA
 biological_processGO:0044597 daunorubicin metabolic process IMP
 biological_processGO:0044598 doxorubicin metabolic process IMP
 biological_processGO:0048385 regulation of retinoic acid receptor signaling pathway IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0055114 oxidation-reduction process TAS
 biological_processGO:0061370 testosterone biosynthetic process IMP
 biological_processGO:0070293 renal absorption NAS
 biological_processGO:0071276 cellular response to cadmium ion IDA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0071379 cellular response to prostaglandin stimulus IDA
 biological_processGO:0071384 cellular response to corticosteroid stimulus IDA
 biological_processGO:0071395 cellular response to jasmonic acid stimulus IDA
 biological_processGO:0071799 cellular response to prostaglandin D stimulus IDA
 biological_processGO:1900053 negative regulation of retinoic acid biosynthetic process IDA
 biological_processGO:2000224 regulation of testosterone biosynthetic process IMP
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IDA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001758 retinal dehydrogenase activity IDA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity IDA
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity TAS
 molecular_functionGO:0004745 retinol dehydrogenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
 molecular_functionGO:0018636 phenanthrene 9,10-monooxygenase activity IDA
 molecular_functionGO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity IDA
 molecular_functionGO:0036130 prostaglandin H2 endoperoxidase reductase activity TAS
 molecular_functionGO:0036131 prostaglandin D2 11-ketoreductase activity TAS
 molecular_functionGO:0045550 geranylgeranyl reductase activity IDA
 molecular_functionGO:0045703 ketoreductase activity IDA
 molecular_functionGO:0047017 prostaglandin-F synthase activity IEA
 molecular_functionGO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity IDA
 molecular_functionGO:0047023 androsterone dehydrogenase activity IDA
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0047086 ketosteroid monooxygenase activity IDA
 molecular_functionGO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA
 molecular_functionGO:0047718 indanol dehydrogenase activity IEA
 molecular_functionGO:0047787 delta4-3-oxosteroid 5beta-reductase activity IDA
 molecular_functionGO:0052650 NADP-retinol dehydrogenase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
RA biosynthesis pathway
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114113 RBP2 / P50120 / retinol binding protein 2  / reaction






 

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