Manteia - Molecule gene

ENSMUSG00000021214

Mus musculus

Features

Gene ID:	ENSMUSG00000021214

Biological name :	Akr1c18

Synonyms :	Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / Q8K023

Possible biological names infered from orthology :	AKR1C1 / AKR1C2 / AKR1C3 / AKR1C4 / aldo-keto reductase family 1 member C1 / aldo-keto reductase family 1 member C2 / aldo-keto reductase family 1 member C3 / aldo-keto reductase family 1 member C4 / P17516 / P42330 / P52895 / Q04828

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	A1
Gene start:	4132615
Gene end:	4150654

Corresponding Affymetrix probe sets:	10407435 (MoGene1.0st) 1419136_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000021635 Ensembl peptide - ENSMUSP00000106332 NCBI entrez gene - 105349 See in Manteia. MGI - MGI:2145420 RefSeq - XM_011244250 RefSeq - NM_001346535 RefSeq - NM_134066 RefSeq Peptide - NP_598827 RefSeq Peptide - NP_001333464 swissprot - Q3U538 swissprot - Q8K023 Ensembl - ENSMUSG00000021214

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
AKR1C1	ENSG00000187134	Homo sapiens
AKR1C2	ENSG00000151632	Homo sapiens
AKR1C3	ENSG00000196139	Homo sapiens
AKR1C4	ENSG00000198610	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...	ENSMUSG00000021207	72
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...	ENSMUSG00000025955	71
Akr1c6 / P70694 / Estradiol 17 beta-dehydrogenase 5 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C4* / aldo-keto re...	ENSMUSG00000021210	71
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000033715	70
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000054757	69
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000071551	67
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000021211	66
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...	ENSMUSG00000021213	65
Akr1d1 / Q8VCX1 / 3-oxo-5-beta-steroid 4-dehydrogenase / P51857* / aldo-keto reductase family 1 member D1*	ENSMUSG00000038641	54
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*	ENSMUSG00000061758	45
Akr1b3 / P45376 / Aldose reductase / AKR1B1* / P15121* / aldo-keto reductase family 1 member B*	ENSMUSG00000001642	45
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*	ENSMUSG00000045410	43
P21300 / Akr1b7 / Aldose reductase-related protein 1 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*	ENSMUSG00000052131	42
P45377 / Akr1b8 / Aldose reductase-related protein 2 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*	ENSMUSG00000029762	42
Akr1a1 / Q9JII6 / Alcohol dehydrogenase [NADP(+)] / P14550* / aldo-keto reductase family 1 member A1*	ENSMUSG00000028692	39

Protein motifs (from Interpro)

Interpro ID	Name
IPR018170	Aldo/keto reductase, conserved site
IPR020471	Aldo/keto reductase
IPR023210	NADP-dependent oxidoreductase domain
IPR036812	NADP-dependent oxidoreductase domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000060	protein import into nucleus, translocation	ISO
biological_process	GO:0006709	progesterone catabolic process	IMP
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	ISO
biological_process	GO:0007565	female pregnancy	IEA
biological_process	GO:0007567	parturition	IMP
biological_process	GO:0008284	positive regulation of cell proliferation	ISO
biological_process	GO:0010942	positive regulation of cell death	ISO
biological_process	GO:0016488	farnesol catabolic process	ISO
biological_process	GO:0034614	cellular response to reactive oxygen species	ISO
biological_process	GO:0042448	progesterone metabolic process	IEA
biological_process	GO:0042574	retinal metabolic process	ISO
biological_process	GO:0044597	daunorubicin metabolic process	ISO
biological_process	GO:0044598	doxorubicin metabolic process	ISO
biological_process	GO:0048385	regulation of retinoic acid receptor signaling pathway	ISO
biological_process	GO:0050810	regulation of steroid biosynthetic process	IEA
biological_process	GO:0051897	positive regulation of protein kinase B signaling	ISO
biological_process	GO:0055114	oxidation-reduction process	ISO
biological_process	GO:0061370	testosterone biosynthetic process	ISO
biological_process	GO:0071276	cellular response to cadmium ion	ISO
biological_process	GO:0071277	cellular response to calcium ion	ISO
biological_process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	IEA
biological_process	GO:0071379	cellular response to prostaglandin stimulus	ISO
biological_process	GO:0071384	cellular response to corticosteroid stimulus	ISO
biological_process	GO:0071394	cellular response to testosterone stimulus	IEA
biological_process	GO:0071395	cellular response to jasmonic acid stimulus	ISO
biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	IEA
biological_process	GO:0071799	cellular response to prostaglandin D stimulus	ISO
biological_process	GO:0097211	cellular response to gonadotropin-releasing hormone	IEA
biological_process	GO:1900053	negative regulation of retinoic acid biosynthetic process	ISO
biological_process	GO:1904322	cellular response to forskolin	IEA
biological_process	GO:1990646	cellular response to prolactin	IEA
biological_process	GO:2000224	regulation of testosterone biosynthetic process	ISO
biological_process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO
biological_process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO
cellular_component	GO:0005622	intracellular	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0001758	retinal dehydrogenase activity	ISO
molecular_function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IEA
molecular_function	GO:0004033	aldo-keto reductase (NADP) activity	IEA
molecular_function	GO:0004745	retinol dehydrogenase activity	ISO
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO
molecular_function	GO:0018636	phenanthrene 9,10-monooxygenase activity	ISO
molecular_function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	ISO
molecular_function	GO:0045550	geranylgeranyl reductase activity	ISO
molecular_function	GO:0045703	ketoreductase activity	ISO
molecular_function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO
molecular_function	GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO
molecular_function	GO:0047023	androsterone dehydrogenase activity	ISO
molecular_function	GO:0047086	ketosteroid monooxygenase activity	ISO
molecular_function	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity	ISO

Pathways (from Reactome)

Pathway description

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

RA biosynthesis pathway

Retinoid metabolism and transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd4^tm1Mak/Cd4^tm1Mak,Cd8a^tm1Mak/Cd8a^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0002293	long gestation period	"increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hsf4^tm1Miv/Hsf4^tm1Miv Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Akr1c18^tm1Mni/Akr1c18^tm1Mni Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005186	increased circulating progesterone level	"greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]	Show Allelic Composition: Akr1c18^tm1Mni/Akr1c18^tm1Mni Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009006	prolonged estrous cycle	"increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Akr1c18^tm1Mni/Akr1c18^tm1Mni Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009011	prolonged diestrus	"increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Akr1c18^tm1Mni/Akr1c18^tm1Mni Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012010	parturition failure	"the process of labor and delivery in female animals does not initiate or complete" [MGI:csmith]	Show Allelic Composition: Hsf4^tm1Miv/Hsf4^tm1Miv Genetic Background: involves: 129S2/SvPas * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr