Manteia

ENSMUSG00000029762

Mus musculus

Features

Gene ID:	ENSMUSG00000029762

Biological name :	Akr1b8

Synonyms :	Akr1b8 / Aldose reductase-related protein 2 / P45377

Possible biological names infered from orthology :	AKR1B10 / AKR1B15 / aldo-keto reductase family 1 member B10 / aldo-keto reductase family 1 member B15 / C9JRZ8 / O60218

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	B1
Gene start:	34354119
Gene end:	34368463

Corresponding Affymetrix probe sets:	10537146 (MoGene1.0st) 1448894_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000040244 NCBI entrez gene - 14187 See in Manteia. MGI - MGI:107673 RefSeq - NM_008012 RefSeq Peptide - NP_032038 swissprot - P45377 Ensembl - ENSMUSG00000029762

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
akr1b1	ENSDARG00000006215	Danio rerio
si:dkey-180p18.9	ENSDARG00000045598	Danio rerio
C9JRZ8	ENSG00000227471	Homo sapiens
O60218	ENSG00000198074	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*	ENSMUSG00000061758	83
P21300 / Akr1b7 / Aldose reductase-related protein 1 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*	ENSMUSG00000052131	82
Akr1b3 / P45376 / Aldose reductase / AKR1B1* / P15121* / aldo-keto reductase family 1 member B*	ENSMUSG00000001642	69
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*	ENSMUSG00000045410	57
Akr1d1 / Q8VCX1 / 3-oxo-5-beta-steroid 4-dehydrogenase / P51857* / aldo-keto reductase family 1 member D1*	ENSMUSG00000038641	50
Akr1a1 / Q9JII6 / Alcohol dehydrogenase [NADP(+)] / P14550* / aldo-keto reductase family 1 member A1*	ENSMUSG00000028692	50
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...	ENSMUSG00000021213	47
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000021211	47
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...	ENSMUSG00000025955	47
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000071551	47
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000054757	45
Akr1c6 / P70694 / Estradiol 17 beta-dehydrogenase 5 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C4* / aldo-keto re...	ENSMUSG00000021210	45
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...	ENSMUSG00000033715	44
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...	ENSMUSG00000021207	44
Q8K023 / Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q0482...	ENSMUSG00000021214	43

Protein motifs (from Interpro)

Interpro ID	Name
IPR018170	Aldo/keto reductase, conserved site
IPR020471	Aldo/keto reductase
IPR023210	NADP-dependent oxidoreductase domain
IPR036812	NADP-dependent oxidoreductase domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0016488	farnesol catabolic process	ISO
biological_process	GO:0044597	daunorubicin metabolic process	ISO
biological_process	GO:0044598	doxorubicin metabolic process	ISO
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0001758	retinal dehydrogenase activity	ISO
molecular_function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0045550	geranylgeranyl reductase activity	ISO
molecular_function	GO:0047718	indanol dehydrogenase activity	ISO

Pathways (from Reactome)

Pathway description

Estrogen biosynthesis

Retinoid metabolism and transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Adipor1^{tm1b(EUCOMM)Hmgu}/Adipor1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Adipor1^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr