ENSMUSG00000001642


Mus musculus

Features
Gene ID: ENSMUSG00000001642
  
Biological name :Akr1b3
  
Synonyms : Akr1b3 / Aldose reductase / P45376
  
Possible biological names infered from orthology : AKR1B1 / aldo-keto reductase family 1 member B / P15121
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 34302434
Gene end: 34317478
  
Corresponding Affymetrix probe sets: 10354768 (MoGene1.0st)   10385236 (MoGene1.0st)   10399457 (MoGene1.0st)   10543859 (MoGene1.0st)   1437133_x_at (Mouse Genome 430 2.0 Array)   1448319_at (Mouse Genome 430 2.0 Array)   1456590_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114391
Ensembl peptide - ENSMUSP00000100045
NCBI entrez gene - 11677     See in Manteia.
MGI - MGI:1353494
RefSeq - NM_009658
RefSeq Peptide - NP_033788
swissprot - D3YVJ7
swissprot - P45376
swissprot - Q3UDY1
Ensembl - ENSMUSG00000001642
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akr1b1ENSDARG00000006215Danio rerio
 si:dkey-180p18.9ENSDARG00000045598Danio rerio
 AKR1B1ENSG00000085662Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*ENSMUSG0000006175870
P45377 / Akr1b8 / Aldose reductase-related protein 2 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000002976269
P21300 / Akr1b7 / Aldose reductase-related protein 1 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000005213169
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*ENSMUSG0000004541059
Akr1d1 / Q8VCX1 / 3-oxo-5-beta-steroid 4-dehydrogenase / P51857* / aldo-keto reductase family 1 member D1*ENSMUSG0000003864150
Akr1c6 / P70694 / Estradiol 17 beta-dehydrogenase 5 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C4* / aldo-keto re...ENSMUSG0000002121050
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000005475750
Akr1a1 / Q9JII6 / Alcohol dehydrogenase [NADP(+)] / P14550* / aldo-keto reductase family 1 member A1*ENSMUSG0000002869250
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000007155149
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000002121149
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...ENSMUSG0000002595549
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002121348
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000003371547
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002120746
Q8K023 / Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q0482...ENSMUSG0000002121446


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0003091 renal water homeostasis IMP
 biological_processGO:0005996 monosaccharide metabolic process IEA
 biological_processGO:0006061 sorbitol biosynthetic process IEA
 biological_processGO:0009414 response to water deprivation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0018931 naphthalene metabolic process IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IEA
 biological_processGO:0035809 regulation of urine volume IMP
 biological_processGO:0042415 norepinephrine metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0044597 daunorubicin metabolic process IEA
 biological_processGO:0044598 doxorubicin metabolic process IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071475 cellular hyperosmotic salinity response IEA
 biological_processGO:0072001 renal system development IMP
 biological_processGO:0072061 inner medullary collecting duct development IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0097238 cellular response to methylglyoxal IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032838 plasma membrane bounded cell projection cytoplasm IEA
 cellular_componentGO:0033010 paranodal junction IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097454 Schwann cell microvillus IEA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0043795 glyceraldehyde oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis
Fructose biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0011229 abnormal vitamin C level "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0011333 abnormal kidney inner medulla morphology "any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [MGI:csmith, PMID:20614633]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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