ENSMUSG00000038641


Mus musculus

Features
Gene ID: ENSMUSG00000038641
  
Biological name :Akr1d1
  
Synonyms : 3-oxo-5-beta-steroid 4-dehydrogenase / Akr1d1 / Q8VCX1
  
Possible biological names infered from orthology : aldo-keto reductase family 1 member D1 / P51857
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B1
Gene start: 37530173
Gene end: 37568815
  
Corresponding Affymetrix probe sets: 10537306 (MoGene1.0st)   1425771_at (Mouse Genome 430 2.0 Array)   1455100_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048830
NCBI entrez gene - 208665     See in Manteia.
MGI - MGI:2384785
RefSeq - XM_017321479
RefSeq - NM_145364
RefSeq - XM_006505826
RefSeq - XM_017321478
RefSeq - XM_006505825
RefSeq Peptide - NP_663339
swissprot - Q8VCX1
Ensembl - ENSMUSG00000038641
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKR1D1ENSGALG00000012834Gallus gallus
 AKR1D1ENSG00000122787Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akr1c6 / P70694 / Estradiol 17 beta-dehydrogenase 5 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C4* / aldo-keto re...ENSMUSG0000002121058
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000005475757
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002120756
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000007155154
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...ENSMUSG0000002595554
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002121353
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000002121153
Q8K023 / Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q0482...ENSMUSG0000002121453
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000003371552
P45377 / Akr1b8 / Aldose reductase-related protein 2 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000002976249
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*ENSMUSG0000006175849
P21300 / Akr1b7 / Aldose reductase-related protein 1 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000005213148
Akr1b3 / P45376 / Aldose reductase / AKR1B1* / P15121* / aldo-keto reductase family 1 member B*ENSMUSG0000000164248
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*ENSMUSG0000004541047
Akr1a1 / Q9JII6 / Alcohol dehydrogenase [NADP(+)] / P14550* / aldo-keto reductase family 1 member A1*ENSMUSG0000002869244


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IEA
 biological_processGO:0007586 digestion IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008207 C21-steroid hormone metabolic process IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030573 bile acid catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047568 3-oxo-5-beta-steroid 4-dehydrogenase activity ISO
 molecular_functionGO:0047787 delta4-3-oxosteroid 5beta-reductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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