ENSMUSG00000028692


Mus musculus

Features
Gene ID: ENSMUSG00000028692
  
Biological name :Akr1a1
  
Synonyms : Akr1a1 / Alcohol dehydrogenase [NADP(+)] / Q9JII6
  
Possible biological names infered from orthology : aldo-keto reductase family 1 member A1 / P14550
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 116636510
Gene end: 116651680
  
Corresponding Affymetrix probe sets: 10515352 (MoGene1.0st)   1430123_a_at (Mouse Genome 430 2.0 Array)   1430124_x_at (Mouse Genome 430 2.0 Array)   1435011_x_at (Mouse Genome 430 2.0 Array)   1451035_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114861
Ensembl peptide - ENSMUSP00000030455
NCBI entrez gene - 58810     See in Manteia.
MGI - MGI:1929955
RefSeq - NM_021473
RefSeq Peptide - NP_067448
swissprot - B1AXW3
swissprot - Q540D7
swissprot - Q9JII6
Ensembl - ENSMUSG00000028692
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akr1a1bENSDARG00000052030Danio rerio
 AKR1A1ENSGALG00000010244Gallus gallus
 AKR1A1ENSG00000117448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P45377 / Akr1b8 / Aldose reductase-related protein 2 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000002976249
P21300 / Akr1b7 / Aldose reductase-related protein 1 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000005213149
Akr1b3 / P45376 / Aldose reductase / AKR1B1* / P15121* / aldo-keto reductase family 1 member B*ENSMUSG0000000164249
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*ENSMUSG0000006175848
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*ENSMUSG0000004541045
Akr1d1 / Q8VCX1 / 3-oxo-5-beta-steroid 4-dehydrogenase / P51857* / aldo-keto reductase family 1 member D1*ENSMUSG0000003864144
Akr1c6 / P70694 / Estradiol 17 beta-dehydrogenase 5 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C4* / aldo-keto re...ENSMUSG0000002121042
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000005475742
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000007155141
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002121341
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000002121140
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002120739
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...ENSMUSG0000002595539
Q8K023 / Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q0482...ENSMUSG0000002121438
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000003371537


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019853 L-ascorbic acid biosynthetic process IDA
 biological_processGO:0042840 D-glucuronate catabolic process IDA
 biological_processGO:0046185 aldehyde catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity TAS
 molecular_functionGO:0008106 alcohol dehydrogenase (NADP+) activity NAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047939 L-glucuronate reductase activity ISO


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Formation of xylulose-5-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0002244 abnormal turbinate morphology "any structural anomaly of the bony plates of the lateral wall of the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

 MP:0011229 abnormal vitamin C level "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
Show

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

Allelic Composition: Akr1a1tm1Maka/Akr1a1tm1Maka
Genetic Background: B6.Cg-Akr1a1tm1Maka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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