ENSMUSG00000052131


Mus musculus

Features
Gene ID: ENSMUSG00000052131
  
Biological name :Akr1b7
  
Synonyms : Akr1b7 / Aldose reductase-related protein 1 / P21300
  
Possible biological names infered from orthology : AKR1B10 / AKR1B15 / aldo-keto reductase family 1 member B10 / aldo-keto reductase family 1 member B15 / C9JRZ8 / O60218
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B1
Gene start: 34412334
Gene end: 34423142
  
Corresponding Affymetrix probe sets: 10537169 (MoGene1.0st)   1423556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007449
NCBI entrez gene - 11997     See in Manteia.
MGI - MGI:101918
RefSeq - NM_009731
RefSeq Peptide - NP_033861
swissprot - P21300
swissprot - Q5M9J9
Ensembl - ENSMUSG00000052131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akr1b1ENSDARG00000006215Danio rerio
 si:dkey-180p18.9ENSDARG00000045598Danio rerio
 C9JRZ8ENSG00000227471Homo sapiens
 O60218ENSG00000198074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*ENSMUSG0000006175885
P45377 / Akr1b8 / Aldose reductase-related protein 2 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000002976282
Akr1b3 / P45376 / Aldose reductase / AKR1B1* / P15121* / aldo-keto reductase family 1 member B*ENSMUSG0000000164269
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*ENSMUSG0000004541058
Akr1a1 / Q9JII6 / Alcohol dehydrogenase [NADP(+)] / P14550* / aldo-keto reductase family 1 member A1*ENSMUSG0000002869250
Akr1d1 / Q8VCX1 / 3-oxo-5-beta-steroid 4-dehydrogenase / P51857* / aldo-keto reductase family 1 member D1*ENSMUSG0000003864149
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...ENSMUSG0000002595547
Akr1c6 / P70694 / Estradiol 17 beta-dehydrogenase 5 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C4* / aldo-keto re...ENSMUSG0000002121046
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000005475746
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000007155146
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000002121146
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002121346
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002120743
Q8K023 / Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q0482...ENSMUSG0000002121443
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000003371543


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0044255 cellular lipid metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0005186 increased circulating progesterone level "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0009292 increased inguinal fat pad weight 
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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