ENSMUSG00000021210


Mus musculus

Features
Gene ID: ENSMUSG00000021210
  
Biological name :Akr1c6
  
Synonyms : Akr1c6 / Estradiol 17 beta-dehydrogenase 5 / P70694
  
Possible biological names infered from orthology : AKR1C1 / AKR1C2 / AKR1C3 / AKR1C4 / aldo-keto reductase family 1 member C1 / aldo-keto reductase family 1 member C2 / aldo-keto reductase family 1 member C3 / aldo-keto reductase family 1 member C4 / P17516 / P42330 / P52895 / Q04828
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 4434306
Gene end: 4457877
  
Corresponding Affymetrix probe sets: 10403322 (MoGene1.0st)   1417085_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021630
Ensembl peptide - ENSMUSP00000152778
Ensembl peptide - ENSMUSP00000152575
Ensembl peptide - ENSMUSP00000117624
NCBI entrez gene - 83702     See in Manteia.
MGI - MGI:1933427
RefSeq - XM_006516510
RefSeq - NM_030611
RefSeq Peptide - NP_085114
swissprot - A0A1Y7VP26
swissprot - D3Z3P8
swissprot - P70694
swissprot - Q3UEM0
swissprot - A0A1Y7VNR7
Ensembl - ENSMUSG00000021210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKR1C1ENSG00000187134Homo sapiens
 AKR1C2ENSG00000151632Homo sapiens
 AKR1C3ENSG00000196139Homo sapiens
 AKR1C4ENSG00000198610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akr1c20 / aldo-keto reductase family 1, member C20 / AKR1C4* / Q04828* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / AKR1C1* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000005475789
Q91WR5 / Akr1c21 / Aldo-keto reductase family 1 member C21 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002120776
Akr1c14 / aldo-keto reductase family 1, member C14 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000003371573
Akr1cl / aldo-keto reductase family 1, member C-like / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-keto re...ENSMUSG0000002595571
Q8K023 / Akr1c18 / Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18), transcript variant 2, mRNA. / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q0482...ENSMUSG0000002121471
Akr1c19 / aldo-keto reductase family 1, member C19 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000007155170
Akr1c12 / aldo-keto reductase family 1, member C12 / AKR1C4* / AKR1C1* / AKR1C2* / AKR1C3* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C2* / aldo-keto redu...ENSMUSG0000002121167
Q8VC28 / Akr1c13 / Aldo-keto reductase family 1 member C13 / AKR1C1* / AKR1C2* / AKR1C3* / AKR1C4* / P17516* / P42330* / P52895* / Q04828* / aldo-keto reductase family 1 member C3* / aldo-...ENSMUSG0000002121366
Akr1d1 / Q8VCX1 / 3-oxo-5-beta-steroid 4-dehydrogenase / P51857* / aldo-keto reductase family 1 member D1*ENSMUSG0000003864159
Akr1b3 / P45376 / Aldose reductase / AKR1B1* / P15121* / aldo-keto reductase family 1 member B*ENSMUSG0000000164249
Akr1b10 / aldo-keto reductase family 1, member B10 (aldose reductase) / O60218* / C9JRZ8* / AKR1B15* / aldo-keto reductase family 1 member B10* / aldo-keto reductase family 1 member B15*ENSMUSG0000006175847
Q9DCT1 / Akr1e1 / 1,5-anhydro-D-fructose reductase / AKR1E2* / Q96JD6* / aldo-keto reductase family 1 member E2*ENSMUSG0000004541045
P21300 / Akr1b7 / Aldose reductase-related protein 1 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000005213145
P45377 / Akr1b8 / Aldose reductase-related protein 2 / C9JRZ8* / O60218* / AKR1B10* / AKR1B15* / aldo-keto reductase family 1 member B15* / aldo-keto reductase family 1 member B10*ENSMUSG0000002976244
Akr1a1 / Q9JII6 / Alcohol dehydrogenase [NADP(+)] / P14550* / aldo-keto reductase family 1 member A1*ENSMUSG0000002869242


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IDA
 biological_processGO:0008202 steroid metabolic process IDA
 biological_processGO:0044597 daunorubicin metabolic process ISO
 biological_processGO:0044598 doxorubicin metabolic process ISO
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071395 cellular response to jasmonic acid stimulus ISO
 molecular_functionGO:0001758 retinal dehydrogenase activity ISO
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity IDA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
 molecular_functionGO:0047023 androsterone dehydrogenase activity ISO


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
RA biosynthesis pathway
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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