ENSG00000198610


Homo sapiens

Features
Gene ID: ENSG00000198610
  
Biological name :AKR1C4
  
Synonyms : AKR1C4 / aldo-keto reductase family 1 member C4 / P17516
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.1
Gene start: 5195462
Gene end: 5218949
  
Corresponding Affymetrix probe sets: 210558_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369814
Ensembl peptide - ENSP00000263126
NCBI entrez gene - 1109     See in Manteia.
OMIM - 600451
RefSeq - NM_001818
RefSeq Peptide - NP_001809
swissprot - P17516
Ensembl - ENSG00000198610
  
Related genetic diseases (OMIM): 614279 - {46XY sex reversal 8, modifier of}, 614279
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Akr1c12ENSMUSG00000021211Mus musculus
 Akr1c14ENSMUSG00000033715Mus musculus
 Akr1c19ENSMUSG00000071551Mus musculus
 Akr1c20ENSMUSG00000054757Mus musculus
 Akr1c6ENSMUSG00000021210Mus musculus
 Akr1clENSMUSG00000025955Mus musculus
 Q8K023ENSMUSG00000021214Mus musculus
 Q8VC28ENSMUSG00000021213Mus musculus
 Q91WR5ENSMUSG00000021207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKR1C3 / P42330 / aldo-keto reductase family 1 member C3ENSG0000019613984
AKR1C1 / Q04828 / aldo-keto reductase family 1 member C1ENSG0000018713483
AKR1C2 / P52895 / aldo-keto reductase family 1 member C2ENSG0000015163281
AKR1D1 / P51857 / aldo-keto reductase family 1 member D1ENSG0000012278757
AKR1B1 / P15121 / aldo-keto reductase family 1 member BENSG0000008566247
O60218 / AKR1B10 / aldo-keto reductase family 1 member B10ENSG0000019807447
C9JRZ8 / AKR1B15 / aldo-keto reductase family 1 member B15ENSG0000022747145
AKR1E2 / Q96JD6 / aldo-keto reductase family 1 member E2ENSG0000016556844
AKR1A1 / P14550 / aldo-keto reductase family 1 member A1ENSG0000011744841


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006699 bile acid biosynthetic process TAS
 biological_processGO:0008202 steroid metabolic process TAS
 biological_processGO:0008209 androgen metabolic process TAS
 biological_processGO:0015721 bile acid and bile salt transport TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0044597 daunorubicin metabolic process IMP
 biological_processGO:0044598 doxorubicin metabolic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071395 cellular response to jasmonic acid stimulus IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001758 retinal dehydrogenase activity IDA
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity TAS
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0015125 bile acid transmembrane transporter activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
 molecular_functionGO:0047023 androsterone dehydrogenase activity IDA
 molecular_functionGO:0047743 chlordecone reductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114113 RBP2 / P50120 / retinol binding protein 2  / reaction






 

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