ENSG00000187134


Homo sapiens

Features
Gene ID: ENSG00000187134
  
Biological name :AKR1C1
  
Synonyms : AKR1C1 / aldo-keto reductase family 1 member C1 / Q04828
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.1
Gene start: 4963253
Gene end: 4983283
  
Corresponding Affymetrix probe sets: 1555854_at (Human Genome U133 Plus 2.0 Array)   1555855_at (Human Genome U133 Plus 2.0 Array)   1555856_s_at (Human Genome U133 Plus 2.0 Array)   204151_x_at (Human Genome U133 Plus 2.0 Array)   209699_x_at (Human Genome U133 Plus 2.0 Array)   211653_x_at (Human Genome U133 Plus 2.0 Array)   216594_x_at (Human Genome U133 Plus 2.0 Array)   217626_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370240
Ensembl peptide - ENSP00000416415
Ensembl peptide - ENSP00000370254
NCBI entrez gene - 1645     See in Manteia.
OMIM - 600449
RefSeq - NM_001353
RefSeq - XM_017015791
RefSeq Peptide - NP_001344
swissprot - A6NHU4
swissprot - Q04828
swissprot - H0Y804
Ensembl - ENSG00000187134
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Akr1c12ENSMUSG00000021211Mus musculus
 Akr1c14ENSMUSG00000033715Mus musculus
 Akr1c19ENSMUSG00000071551Mus musculus
 Akr1c20ENSMUSG00000054757Mus musculus
 Akr1c6ENSMUSG00000021210Mus musculus
 Akr1clENSMUSG00000025955Mus musculus
 Q8K023ENSMUSG00000021214Mus musculus
 Q8VC28ENSMUSG00000021213Mus musculus
 Q91WR5ENSMUSG00000021207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKR1C2 / P52895 / aldo-keto reductase family 1 member C2ENSG0000015163298
AKR1C3 / P42330 / aldo-keto reductase family 1 member C3ENSG0000019613988
AKR1C4 / P17516 / aldo-keto reductase family 1 member C4ENSG0000019861083
AKR1D1 / P51857 / aldo-keto reductase family 1 member D1ENSG0000012278758
AKR1B1 / P15121 / aldo-keto reductase family 1 member BENSG0000008566248
O60218 / AKR1B10 / aldo-keto reductase family 1 member B10ENSG0000019807447
C9JRZ8 / AKR1B15 / aldo-keto reductase family 1 member B15ENSG0000022747144
AKR1A1 / P14550 / aldo-keto reductase family 1 member A1ENSG0000011744842
AKR1E2 / Q96JD6 / aldo-keto reductase family 1 member E2ENSG0000016556842


Protein motifs (from Interpro)
Interpro ID Name
 IPR018170  Aldo/keto reductase, conserved site
 IPR020471  Aldo/keto reductase
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006805 xenobiotic metabolic process NAS
 biological_processGO:0007586 digestion IDA
 biological_processGO:0008206 bile acid metabolic process IDA
 biological_processGO:0015721 bile acid and bile salt transport TAS
 biological_processGO:0030299 intestinal cholesterol absorption TAS
 biological_processGO:0030855 epithelial cell differentiation IDA
 biological_processGO:0042448 progesterone metabolic process IDA
 biological_processGO:0042574 retinal metabolic process IDA
 biological_processGO:0042632 cholesterol homeostasis TAS
 biological_processGO:0044597 daunorubicin metabolic process IMP
 biological_processGO:0044598 doxorubicin metabolic process IMP
 biological_processGO:0046683 response to organophosphorus IEP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071395 cellular response to jasmonic acid stimulus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity IDA
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
 molecular_functionGO:0018636 phenanthrene 9,10-monooxygenase activity IDA
 molecular_functionGO:0031406 carboxylic acid binding IDA
 molecular_functionGO:0032052 bile acid binding IDA
 molecular_functionGO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IEA
 molecular_functionGO:0047042 androsterone dehydrogenase (B-specific) activity IDA
 molecular_functionGO:0047086 ketosteroid monooxygenase activity IDA
 molecular_functionGO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA
 molecular_functionGO:0047718 indanol dehydrogenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114113 RBP2 / P50120 / retinol binding protein 2  / reaction






 

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