ENSG00000130726


Homo sapiens

Features
Gene ID: ENSG00000130726
  
Biological name :TRIM28
  
Synonyms : Q13263 / TRIM28 / tripartite motif containing 28
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.43
Gene start: 58544091
Gene end: 58550722
  
Corresponding Affymetrix probe sets: 200990_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472586
Ensembl peptide - ENSP00000473126
Ensembl peptide - ENSP00000253024
Ensembl peptide - ENSP00000342232
Ensembl peptide - ENSP00000470503
Ensembl peptide - ENSP00000471303
NCBI entrez gene - 10155     See in Manteia.
OMIM - 601742
RefSeq - NM_005762
RefSeq Peptide - NP_005753
swissprot - M0R2I3
swissprot - M0R3C0
swissprot - Q13263
swissprot - M0QZE6
swissprot - M0R0K9
Ensembl - ENSG00000130726
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q62318ENSMUSG00000005566Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UPN9 / TRIM33 / tripartite motif containing 33ENSG0000019732332
O15164 / TRIM24 / tripartite motif containing 24ENSG0000012277930
O15016 / TRIM66 / tripartite motif containing 66ENSG0000016643624
Q2Q1W2 / TRIM71 / tripartite motif containing 71ENSG0000020655715
TRIM2 / Q9C040 / tripartite motif containing 2ENSG0000010965413
Q9H8W5 / TRIM45 / tripartite motif containing 45ENSG0000013425312
TRIM3 / O75382 / tripartite motif containing 3ENSG0000011017112
Q9BRZ2 / TRIM56 / tripartite motif containing 56ENSG0000016987111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001487  Bromodomain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003649  B-box, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036427  Bromodomain-like superfamily
 IPR037373  Transcription intermediary factor 1-beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001837 epithelial to mesenchymal transition ISS
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IDA
 biological_processGO:0043045 DNA methylation involved in embryo development IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0045739 positive regulation of DNA repair IDA
 biological_processGO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0060028 convergent extension involved in axis elongation IEA
 biological_processGO:0060669 embryonic placenta morphogenesis IEA
 biological_processGO:0090309 positive regulation of methylation-dependent chromatin silencing IMP
 biological_processGO:1901536 negative regulation of DNA demethylation IEA
 biological_processGO:1902187 negative regulation of viral release from host cell IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000653 regulation of genetic imprinting IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005720 nuclear heterochromatin IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISS
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0035851 Krueppel-associated box domain binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070087 chromo shadow domain binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway
SUMOylation of transcription cofactors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124459 ZNF45 / Q02386 / zinc finger protein 45  / complex / reaction
 ENSG00000256683 Q9GZX5 / ZNF350 / zinc finger protein 350  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr