ENSMUSG00000005566


Mus musculus

Features
Gene ID: ENSMUSG00000005566
  
Biological name :Trim28
  
Synonyms : Q62318 / Trim28 / tripartite motif-containing 28
  
Possible biological names infered from orthology : Q13263
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 12999114
Gene end: 13031035
  
Corresponding Affymetrix probe sets: 10550076 (MoGene1.0st)   1415869_a_at (Mouse Genome 430 2.0 Array)   1456308_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005705
NCBI entrez gene - 21849     See in Manteia.
MGI - MGI:109274
RefSeq - NM_011588
RefSeq Peptide - NP_035718
swissprot - Q5EBP9
swissprot - Q62318
Ensembl - ENSMUSG00000005566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q13263ENSG00000130726Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim33 / tripartite motif containing 33 / Q9UPN9*ENSMUSG0000003301432
Q64127 / Trim24 / Transcription intermediary factor 1-alpha / O15164* / tripartite motif containing 24*ENSMUSG0000002983329
Q924W6 / Trim66 / tripartite motif-containing 66 / O15016*ENSMUSG0000003102623
Q1PSW8 / Trim71 / tripartite motif-containing 71 / Q2Q1W2*ENSMUSG0000007925915
Q6PFY8 / Trim45 / Tripartite motif-containing protein 45 / Q9H8W5* / tripartite motif containing 45*ENSMUSG0000003323314
Trim2 / Q9ESN6 / tripartite motif-containing 2 / Q9C040*ENSMUSG0000002799313
Trim3 / Q9R1R2 / tripartite motif-containing 3 / O75382*ENSMUSG0000003698912
Trim56 / tripartite motif containing 56 / Q9BRZ2*ENSMUSG0000004327911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001487  Bromodomain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003649  B-box, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036427  Bromodomain-like superfamily
 IPR037373  Transcription intermediary factor 1-beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016925 protein sumoylation ISO
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0043045 DNA methylation involved in embryo development IMP
 biological_processGO:0043388 positive regulation of DNA binding IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060669 embryonic placenta morphogenesis IMP
 biological_processGO:0090309 positive regulation of methylation-dependent chromatin silencing IEA
 biological_processGO:1901536 negative regulation of DNA demethylation IMP
 biological_processGO:1902187 negative regulation of viral release from host cell IEA
 biological_processGO:2000653 regulation of genetic imprinting IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035851 Krueppel-associated box domain binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070087 chromo shadow domain binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

Allelic Composition: Trim28chatwo/Trim28tm1.2Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnao1tm2.1Rneu/Gnao1+
Genetic Background: B6.129S-Gnao1tm2.1Rneu

Allelic Composition: Trim28chatwo/Trim28+,Zfp568chato/Zfp568chato
Genetic Background: involves: C57BL/6J

Allelic Composition: Trim28chatwo/Trim28chatwo,Zfp568chato/Zfp568+
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Trim28chatwo/Trim28+,Zfp568chato/Zfp568+
Genetic Background: involves: C57BL/6J

 MP:0002210 abnormal sex determination "anomaly of primary or secondary sexual development or characteristics" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004558 delayed allantois development "late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

Allelic Composition: Trim28chatwo/Trim28tm1.2Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ank1M1Wlst/Ank1+
Genetic Background: C3.B6-Ank1M1Wlst

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0011202 abnormal ectoplacental cavity morphology "any structural anomaly of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0011203 abnormal parietal yolk sac morphology "any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert s membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0012180 abnormal somatic mesoderm morphology "any structural abnormality of the outer layer of lateral plate mesoderm, located under (ventrally) the ectoderm, which forms the future body wall" [MGI:anna]
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Allelic Composition: Trim28chatwo/Trim28chatwo
Genetic Background: either: C57BL/6-Trim28chatwo or (involves: C57BL/6J * FVB/NJ)

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
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Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074282 Zfp94 / zinc finger protein 94 / ZNF45* / Q02386* / zinc finger protein 45*  / complex / reaction






 

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