ENSMUSG00000033014


Mus musculus

Features
Gene ID: ENSMUSG00000033014
  
Biological name :Trim33
  
Synonyms : Trim33 / tripartite motif containing 33
  
Possible biological names infered from orthology : Q9UPN9
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 103279293
Gene end: 103358775
  
Corresponding Affymetrix probe sets: 10494924 (MoGene1.0st)   1426954_at (Mouse Genome 430 2.0 Array)   1455189_at (Mouse Genome 430 2.0 Array)   1459264_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029444
Ensembl peptide - ENSMUSP00000143749
Ensembl peptide - ENSMUSP00000143117
Ensembl peptide - ENSMUSP00000142585
Ensembl peptide - ENSMUSP00000102473
NCBI entrez gene - 94093     See in Manteia.
MGI - MGI:2137357
RefSeq - NM_053170
RefSeq - NM_001079830
RefSeq Peptide - NP_444400
RefSeq Peptide - NP_001073299
swissprot - A0A0G2JFC3
swissprot - A0A0G2JGY5
swissprot - E9QME5
swissprot - E9QP19
swissprot - A0A0G2JE09
Ensembl - ENSMUSG00000033014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim33ENSDARG00000016181Danio rerio
 TRIM33ENSGALG00000001976Gallus gallus
 Q9UPN9ENSG00000197323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64127 / Trim24 / Transcription intermediary factor 1-alpha / O15164* / tripartite motif containing 24*ENSMUSG0000002983346
Q924W6 / Trim66 / tripartite motif-containing 66 / O15016*ENSMUSG0000003102628
Q62318 / Trim28 / tripartite motif-containing 28 / Q13263*ENSMUSG0000000556623
Trim2 / Q9ESN6 / tripartite motif-containing 2 / Q9C040*ENSMUSG0000002799311
Q1PSW8 / Trim71 / tripartite motif-containing 71 / Q2Q1W2*ENSMUSG0000007925911
Q6PFY8 / Trim45 / Tripartite motif-containing protein 45 / Q9H8W5* / tripartite motif containing 45*ENSMUSG0000003323311
Trim3 / Q9R1R2 / tripartite motif-containing 3 / O75382*ENSMUSG0000003698911
Trim56 / tripartite motif containing 56 / Q9BRZ2*ENSMUSG000000432799


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001487  Bromodomain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003649  B-box, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070410 co-SMAD binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Tg(CAG-cre)13Miya/0,Trim33tm1.1Los/Trim33tm1.2Los
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * SJL

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Tg(CAG-cre)13Miya/0,Trim33tm1.1Los/Trim33tm1.2Los
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * SJL

 MP:0009110 pancreas hyperplasia "overdevelopment or increased size of the pancreas, usually due an increased number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009144 dilated pancreatic duct "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
Show

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009152 pancreatic intraepithelial neoplasia "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]
Show

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Trim33tm1Los/Trim33tm1Los,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
Show

Allelic Composition: Trim33tm1.2Los/Trim33tm1.2Los
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0012160 expanded anterior visceral endoderm "the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue occupies a greater area in the extraembryonic region" [MGI:anna]
Show

Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
Show

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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