ENSMUSG00000027993


Mus musculus

Features
Gene ID: ENSMUSG00000027993
  
Biological name :Trim2
  
Synonyms : Q9ESN6 / Trim2 / tripartite motif-containing 2
  
Possible biological names infered from orthology : Q9C040
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 84160439
Gene end: 84306877
  
Corresponding Affymetrix probe sets: 10499045 (MoGene1.0st)   1417027_at (Mouse Genome 430 2.0 Array)   1417028_a_at (Mouse Genome 430 2.0 Array)   1417029_a_at (Mouse Genome 430 2.0 Array)   1441487_at (Mouse Genome 430 2.0 Array)   1448551_a_at (Mouse Genome 430 2.0 Array)   1459860_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103323
Ensembl peptide - ENSMUSP00000103321
Ensembl peptide - ENSMUSP00000115914
Ensembl peptide - ENSMUSP00000121055
Ensembl peptide - ENSMUSP00000120981
Ensembl peptide - ENSMUSP00000118888
Ensembl peptide - ENSMUSP00000049902
Ensembl peptide - ENSMUSP00000069922
Ensembl peptide - ENSMUSP00000103319
Ensembl peptide - ENSMUSP00000103320
NCBI entrez gene - 80890     See in Manteia.
MGI - MGI:1933163
RefSeq - XM_017319815
RefSeq - XM_011240296
RefSeq - XM_011240297
RefSeq - XM_011240298
RefSeq - XM_011240299
RefSeq - XM_011240300
RefSeq - XM_011240301
RefSeq - XM_011240302
RefSeq - XM_011240303
RefSeq - XM_011240304
RefSeq - XM_011240305
RefSeq - XM_017319813
RefSeq - XM_017319814
RefSeq - NM_001271725
RefSeq - NM_001271726
RefSeq - NM_001271727
RefSeq - NM_001271728
RefSeq - NM_030706
RefSeq Peptide - NP_109631
RefSeq Peptide - NP_001258657
RefSeq Peptide - NP_001258654
RefSeq Peptide - NP_001258655
RefSeq Peptide - NP_001258656
swissprot - Q9ESN6
swissprot - D3YTN5
swissprot - Q3UHH4
swissprot - D3YZJ0
swissprot - D3YY69
swissprot - D3YY12
swissprot - E9QKC6
Ensembl - ENSMUSG00000027993
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim2aENSDARG00000031817Danio rerio
 trim2bENSDARG00000076174Danio rerio
 TRIM2ENSGALG00000009207Gallus gallus
 TRIM2ENSG00000109654Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim3 / Q9R1R2 / tripartite motif-containing 3 / O75382*ENSMUSG0000003698965
Q1PSW8 / Trim71 / tripartite motif-containing 71 / Q2Q1W2*ENSMUSG0000007925929
Trim33 / tripartite motif containing 33 / Q9UPN9*ENSMUSG0000003301417
Trim56 / tripartite motif containing 56 / Q9BRZ2*ENSMUSG0000004327917
Q6PFY8 / Trim45 / Tripartite motif-containing protein 45 / Q9H8W5* / tripartite motif containing 45*ENSMUSG0000003323317
Q64127 / Trim24 / Transcription intermediary factor 1-alpha / O15164* / tripartite motif containing 24*ENSMUSG0000002983315
Q924W6 / Trim66 / tripartite motif-containing 66 / O15016*ENSMUSG0000003102615
Q62318 / Trim28 / tripartite motif-containing 28 / Q13263*ENSMUSG0000000556614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001258  NHL repeat
 IPR001298  Filamin/ABP280 repeat
 IPR001841  Zinc finger, RING-type
 IPR003649  B-box, C-terminal
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013017  NHL repeat, subgroup
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR017868  Filamin/ABP280 repeat-like
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm NAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017022 myosin binding NAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009979 abnormal cerebellum deep nucleus morphology "any structural anomaly of the gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei" [http://www.spiritus-temporis.com/cerebellum/anatomy.html]
Show

Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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