ENSMUSG00000079259


Mus musculus

Features
Gene ID: ENSMUSG00000079259
  
Biological name :Trim71
  
Synonyms : Q1PSW8 / Trim71 / tripartite motif-containing 71
  
Possible biological names infered from orthology : Q2Q1W2
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 114507133
Gene end: 114564369
  
Corresponding Affymetrix probe sets: 10597427 (MoGene1.0st)   1453599_at (Mouse Genome 430 2.0 Array)   1456673_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107447
NCBI entrez gene - 636931     See in Manteia.
MGI - MGI:2685973
RefSeq - NM_001042503
RefSeq Peptide - NP_001035968
swissprot - Q1PSW8
Ensembl - ENSMUSG00000079259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7FAM5ENSDARG00000075593Danio rerio
 TRIM71ENSGALG00000019622Gallus gallus
 Q2Q1W2ENSG00000206557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim3 / Q9R1R2 / tripartite motif-containing 3 / O75382*ENSMUSG0000003698928
Trim2 / Q9ESN6 / tripartite motif-containing 2 / Q9C040*ENSMUSG0000002799326
Q6PFY8 / Trim45 / Tripartite motif-containing protein 45 / Q9H8W5* / tripartite motif containing 45*ENSMUSG0000003323316
Trim33 / tripartite motif containing 33 / Q9UPN9*ENSMUSG0000003301415
Q62318 / Trim28 / tripartite motif-containing 28 / Q13263*ENSMUSG0000000556615
Q64127 / Trim24 / Transcription intermediary factor 1-alpha / O15164* / tripartite motif containing 24*ENSMUSG0000002983315
Q924W6 / Trim66 / tripartite motif-containing 66 / O15016*ENSMUSG0000003102614
Trim56 / tripartite motif containing 56 / Q9BRZ2*ENSMUSG0000004327914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001258  NHL repeat
 IPR001298  Filamin/ABP280 repeat
 IPR001841  Zinc finger, RING-type
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013017  NHL repeat, subgroup
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR017868  Filamin/ABP280 repeat-like
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0010586 miRNA metabolic process IDA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0021915 neural tube development IDA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IMP
 biological_processGO:0051246 regulation of protein metabolic process IDA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0060964 regulation of gene silencing by miRNA IMP
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0072089 stem cell proliferation IMP
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IMP
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030371 translation repressor activity IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0012680 absent lateral ventricles "absence of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; lateral ventricles are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MGI:anna]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0012686 everted embryonic neuroepithelium "an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly" [MGI:anna]
Show

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr