ENSMUSG00000033233


Mus musculus

Features
Gene ID: ENSMUSG00000033233
  
Biological name :Trim45
  
Synonyms : Q6PFY8 / Trim45 / Tripartite motif-containing protein 45
  
Possible biological names infered from orthology : Q9H8W5 / tripartite motif containing 45
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 100922202
Gene end: 100936920
  
Corresponding Affymetrix probe sets: 10494769 (MoGene1.0st)   1441412_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043389
Ensembl peptide - ENSMUSP00000091590
Ensembl peptide - ENSMUSP00000102593
Ensembl peptide - ENSMUSP00000115669
NCBI entrez gene - 229644     See in Manteia.
MGI - MGI:1918187
RefSeq - XM_011240100
RefSeq - NM_001165952
RefSeq - NM_001165953
RefSeq - NM_194343
RefSeq Peptide - NP_001159424
RefSeq Peptide - NP_001159425
RefSeq Peptide - NP_919324
swissprot - Q6PFY8
swissprot - A2ACL2
Ensembl - ENSMUSG00000033233
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim45ENSDARG00000076781Danio rerio
 TRIM45ENSGALG00000014818Gallus gallus
 Q9H8W5ENSG00000134253Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim2 / Q9ESN6 / tripartite motif-containing 2 / Q9C040*ENSMUSG0000002799318
Q1PSW8 / Trim71 / tripartite motif-containing 71 / Q2Q1W2*ENSMUSG0000007925918
Trim56 / tripartite motif containing 56 / Q9BRZ2*ENSMUSG0000004327918
Trim3 / Q9R1R2 / tripartite motif-containing 3 / O75382*ENSMUSG0000003698918
Trim33 / tripartite motif containing 33 / Q9UPN9*ENSMUSG0000003301416
Q64127 / Trim24 / Transcription intermediary factor 1-alpha / O15164* / tripartite motif containing 24*ENSMUSG0000002983316
Q62318 / Trim28 / tripartite motif-containing 28 / Q13263*ENSMUSG0000000556615
Q924W6 / Trim66 / tripartite motif-containing 66 / O15016*ENSMUSG0000003102613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001298  Filamin/ABP280 repeat
 IPR001841  Zinc finger, RING-type
 IPR003649  B-box, C-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR017868  Filamin/ABP280 repeat-like
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060348 bone development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013840 absent segment of posterior cerebral artery "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
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Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013859 abnormal vitelline vein connection "aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013971 blood in lymph vessels 
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0014003 additional anastomosis between intracranial vertebral arteries 
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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