ENSMUSG00000029833


Mus musculus

Features
Gene ID: ENSMUSG00000029833
  
Biological name :Trim24
  
Synonyms : Q64127 / Transcription intermediary factor 1-alpha / Trim24
  
Possible biological names infered from orthology : O15164 / tripartite motif containing 24
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B1
Gene start: 37870811
Gene end: 37966296
  
Corresponding Affymetrix probe sets: 10537318 (MoGene1.0st)   1427258_at (Mouse Genome 430 2.0 Array)   1427259_at (Mouse Genome 430 2.0 Array)   1446295_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031859
Ensembl peptide - ENSMUSP00000113063
Ensembl peptide - ENSMUSP00000114001
NCBI entrez gene - 21848     See in Manteia.
MGI - MGI:109275
RefSeq - XM_006505895
RefSeq - NM_001272064
RefSeq - NM_001272076
RefSeq - NM_145076
RefSeq Peptide - NP_001258993
RefSeq Peptide - NP_001259005
RefSeq Peptide - NP_659542
swissprot - Q64127
swissprot - E9Q1U8
Ensembl - ENSMUSG00000029833
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRIM24ENSGALG00000012823Gallus gallus
 O15164ENSG00000122779Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim33 / tripartite motif containing 33 / Q9UPN9*ENSMUSG0000003301450
Q924W6 / Trim66 / tripartite motif-containing 66 / O15016*ENSMUSG0000003102629
Q62318 / Trim28 / tripartite motif-containing 28 / Q13263*ENSMUSG0000000556623
Q1PSW8 / Trim71 / tripartite motif-containing 71 / Q2Q1W2*ENSMUSG0000007925912
Q6PFY8 / Trim45 / Tripartite motif-containing protein 45 / Q9H8W5* / tripartite motif containing 45*ENSMUSG0000003323312
Trim3 / Q9R1R2 / tripartite motif-containing 3 / O75382*ENSMUSG0000003698911
Trim2 / Q9ESN6 / tripartite motif-containing 2 / Q9C040*ENSMUSG0000002799311
Trim56 / tripartite motif containing 56 / Q9BRZ2*ENSMUSG000000432799


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001487  Bromodomain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003649  B-box, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018359  Bromodomain, conserved site
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0070562 regulation of vitamin D receptor signaling pathway IMP
 biological_processGO:0071391 cellular response to estrogen stimulus ISS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005726 perichromatin fibrils IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016922 nuclear receptor binding IDA
 molecular_functionGO:0034056 estrogen response element binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0070577 lysine-acetylated histone binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc26a5mpc234H/Slc26a5mpc234H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Raratm3.1Ipc/Rara+,Trim24tm1.1Los/Trim24tm1.1Los
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Raratm3Ipc/Raratm3Ipc,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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