Manteia

ENSG00000131042

Homo sapiens

Features

Gene ID:	ENSG00000131042

Biological name :	LILRB2

Synonyms :	leukocyte immunoglobulin like receptor B2 / LILRB2 / Q8N423

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	19
Strand:	-1
Band:	q13.42
Gene start:	54273821
Gene end:	54281184

Corresponding Affymetrix probe sets:	207697_x_at (Human Genome U133 Plus 2.0 Array) 210146_x_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000394130 Ensembl peptide - ENSP00000375629 Ensembl peptide - ENSP00000410117 Ensembl peptide - ENSP00000319960 Ensembl peptide - ENSP00000375626 Ensembl peptide - ENSP00000375628 NCBI entrez gene - 10288 See in Manteia. OMIM - 604815 RefSeq - NM_005874 RefSeq - NM_001278405 RefSeq - NM_001278406 RefSeq - NM_001080978 RefSeq - NM_001278403 RefSeq - NM_001278404 RefSeq Peptide - NP_001265335 RefSeq Peptide - NP_001265333 swissprot - Q8N423 swissprot - A2IXV5 swissprot - H7C0C3 Ensembl - ENSG00000131042

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name

Species

No match

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
LILRB1 / leukocyte immunoglobulin like receptor B1	ENSG00000104972	85
LILRB5 / O75023 / leukocyte immunoglobulin like receptor B5	ENSG00000105609	67
LILRB3 / O75022 / leukocyte immunoglobulin like receptor B3	ENSG00000204577	66
LILRA1 / O75019 / leukocyte immunoglobulin like receptor A1	ENSG00000104974	62
LILRA2 / Q8N149 / leukocyte immunoglobulin like receptor A2	ENSG00000239998	59
LILRA6 / Q6PI73 / leukocyte immunoglobulin like receptor A6	ENSG00000244482	51
LILRA4 / P59901 / leukocyte immunoglobulin like receptor A4	ENSG00000239961	49
LILRB4 / Q8NHJ6 / leukocyte immunoglobulin like receptor B4	ENSG00000186818	37
P43630 / KIR3DL2 / killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	ENSG00000240403	26
P43629 / KIR3DL1 / killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	ENSG00000167633	25
KIR3DL3 / killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3	ENSG00000242019	25
A6NI73 / LILRA5 / leukocyte immunoglobulin like receptor A5	ENSG00000187116	23
P43628 / KIR2DL3 / killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	ENSG00000243772	21
GP6 / Q9HCN6 / glycoprotein VI platelet	ENSG00000088053	21
P43626 / KIR2DL1 / killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	ENSG00000125498	20
Q9H7L2 / KIR3DX1 / killer cell immunoglobulin like receptor, three Ig domains X1	ENSG00000104970	19
Q99706 / KIR2DL4 / killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	ENSG00000189013	18
NCR1 / O76036 / natural cytotoxicity triggering receptor 1	ENSG00000189430	18
FCAR / P24071 / Fc fragment of IgA receptor	ENSG00000186431	16
KIR2DS4 / killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4	ENSG00000221957	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR013783	Immunoglobulin-like fold
IPR016332	Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor
IPR021157	Cytochrome c1, transmembrane anchor, C-terminal
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002578	negative regulation of antigen processing and presentation	IDA
biological_process	GO:0002645	positive regulation of tolerance induction	IMP
biological_process	GO:0002666	positive regulation of T cell tolerance induction	IMP
biological_process	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	IMP
biological_process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	IDA
biological_process	GO:0006955	immune response	TAS
biological_process	GO:0006968	cellular defense response	TAS
biological_process	GO:0007165	signal transduction	IMP
biological_process	GO:0007166	cell surface receptor signaling pathway	TAS
biological_process	GO:0007267	cell-cell signaling	TAS
biological_process	GO:0007611	learning or memory	ISS
biological_process	GO:0032755	positive regulation of interleukin-6 production	NAS
biological_process	GO:0034113	heterotypic cell-cell adhesion	IDA
biological_process	GO:0035307	positive regulation of protein dephosphorylation	ISS
biological_process	GO:0042102	positive regulation of T cell proliferation	IDA
biological_process	GO:0042130	negative regulation of T cell proliferation	IMP
biological_process	GO:0043312	neutrophil degranulation	TAS
biological_process	GO:0045591	positive regulation of regulatory T cell differentiation	IMP
biological_process	GO:0050776	regulation of immune response	TAS
biological_process	GO:0051248	negative regulation of protein metabolic process	ISS
biological_process	GO:0051926	negative regulation of calcium ion transport	IDA
biological_process	GO:0071222	cellular response to lipopolysaccharide	IMP
biological_process	GO:1900271	regulation of long-term synaptic potentiation	ISS
biological_process	GO:1900454	positive regulation of long term synaptic depression	ISS
biological_process	GO:1905875	negative regulation of postsynaptic density organization	IC
biological_process	GO:2001198	regulation of dendritic cell differentiation	IC
cellular_component	GO:0005615	extracellular space	IDA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	IC
cellular_component	GO:0009986	cell surface	IDA
cellular_component	GO:0016020	membrane	TAS
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0070821	tertiary granule membrane	TAS
cellular_component	GO:0101003	ficolin-1-rich granule membrane	TAS
cellular_component	GO:0106003	amyloid-beta complex	IDA
molecular_function	GO:0001540	amyloid-beta binding	IMP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008157	protein phosphatase 1 binding	IPI
molecular_function	GO:0023029	MHC class Ib protein binding	IPI
molecular_function	GO:0032396	inhibitory MHC class I receptor activity	IMP
molecular_function	GO:0042288	MHC class I protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IDA
molecular_function	GO:0044877	protein-containing complex binding	IPI
molecular_function	GO:0050839	cell adhesion molecule binding	IPI

Pathways (from Reactome)

Pathway description

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000166710	B2M / P61769 / beta-2-microglobulin	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr