ENSG00000181965


Homo sapiens

Features
Gene ID: ENSG00000181965
  
Biological name :NEUROG1
  
Synonyms : NEUROG1 / neurogenin 1 / Q92886
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 135534282
Gene end: 135535949
  
Corresponding Affymetrix probe sets: 208497_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000317580
NCBI entrez gene - 4762     See in Manteia.
OMIM - 601726
RefSeq - NM_006161
RefSeq Peptide - NP_006152
swissprot - F1T0H3
swissprot - Q92886
Ensembl - ENSG00000181965
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEUROG1ENSGALG00000029692Gallus gallus
 P70660ENSMUSG00000048904Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H2A3 / NEUROG2 / neurogenin 2ENSG0000017840339
Q9Y4Z2 / NEUROG3 / neurogenin 3ENSG0000012285937
Q15784 / NEUROD2 / neuronal differentiation 2ENSG0000017153228
Q13562 / NEUROD1 / neuronal differentiation 1ENSG0000016299228
Q9HD90 / NEUROD4 / neuronal differentiation 4ENSG0000012330727
Q96NK8 / NEUROD6 / neuronal differentiation 6ENSG0000016460026
ATOH1 / Q92858 / atonal bHLH transcription factor 1ENSG0000017223825
ATOH7 / Q8N100 / atonal bHLH transcription factor 7ENSG0000017977419
ATOH8 / Q96SQ7 / atonal bHLH transcription factor 8ENSG0000016887419
Q7RTS1 / BHLHA15 / basic helix-loop-helix family member a15ENSG0000018053519


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032653  Neurogenin-1
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007356 thorax and anterior abdomen determination IGI
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0021559 trigeminal nerve development IGI
 biological_processGO:0021650 vestibulocochlear nerve formation IGI
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030432 peristalsis IGI
 biological_processGO:0031223 auditory behavior IGI
 biological_processGO:0031536 positive regulation of exit from mitosis IEA
 biological_processGO:0035112 genitalia morphogenesis IGI
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048634 regulation of muscle organ development IGI
 biological_processGO:0048806 genitalia development IGI
 biological_processGO:0048839 inner ear development IGI
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0071626 mastication IGI
 biological_processGO:0090102 cochlea development IGI
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0097094 craniofacial suture morphogenesis IGI
 biological_processGO:0098583 learned vocalization behavior IGI
 biological_processGO:1901078 negative regulation of relaxation of muscle IGI
 biological_processGO:1905747 negative regulation of saliva secretion IGI
 biological_processGO:1905748 hard palate morphogenesis IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding ISS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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